Acute Liver Failure due to Amanita phalloides Poisoning: Therapeutic Approach and Outcome

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00076541" target="_blank" >RIV/00023001:_____/18:00076541 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.transplantation-proceedings.org/article/S0041-1345(17)30850-3/pdf" target="_blank" >http://www.transplantation-proceedings.org/article/S0041-1345(17)30850-3/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.transproceed.2017.11.032" target="_blank" >10.1016/j.transproceed.2017.11.032</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Acute Liver Failure due to Amanita phalloides Poisoning: Therapeutic Approach and Outcome

Popis výsledku v původním jazyce

Introduction. Amanita phalloides poisoning is a potentially fatal cause of acute liver failure. The aim of this study was to analyze the impact of initial patients&apos; characteristics and different treatment modalities on the outcome of patients with liver failure caused by Amanita poisoning. Material and methods. We retrospectively evaluated 23 patients admitted to our center between July 2007 and August 2016. Results. Mean time interval between Amanita phalloides ingestion and the onset of gastrointestinal symptoms was 12.48 + 9.88 hours and the interval between ingestion and hospital admission 26.26 +/- 15.14 hours. The treatment was intiated by oral decontamination using activated charcoal followed by intravenous rehydration and high doses of intravenous N-acetylcysteine and silibinin. Fourteen patients (61%) underwent extracorporeal elimination method. Ten patients had plasmapheresis, 1 patient had hemoperfusion, and 5 patients had fractionated plasma separation and adsorption. Seven patients who met King&apos;s College Criteria were listed for urgent liver transplantation; one of them died before transplantation. Six patients underwent liver transplantation; the mean waiting time was 6.5 +/- 12.0 days (range, 1-31 days). One patient died 2 months afterward. All 16 patients who did not meet King&apos;s College Criteria and received conservative treatment survived. Conclusion. Our results documented a good prognostic value of standard King&apos;s College Criteria for indication of urgent liver transplantation in acute liver failure caused by Amanita phalloides poisoning. Fractionated plasma separation and adsorption may contribute to low mortality on the waiting list. Intensive care and extracorporeal elimination methods seem to be crucial points of the conservative treatment.

Název v anglickém jazyce

Acute Liver Failure due to Amanita phalloides Poisoning: Therapeutic Approach and Outcome

Popis výsledku anglicky

Introduction. Amanita phalloides poisoning is a potentially fatal cause of acute liver failure. The aim of this study was to analyze the impact of initial patients&apos; characteristics and different treatment modalities on the outcome of patients with liver failure caused by Amanita poisoning. Material and methods. We retrospectively evaluated 23 patients admitted to our center between July 2007 and August 2016. Results. Mean time interval between Amanita phalloides ingestion and the onset of gastrointestinal symptoms was 12.48 + 9.88 hours and the interval between ingestion and hospital admission 26.26 +/- 15.14 hours. The treatment was intiated by oral decontamination using activated charcoal followed by intravenous rehydration and high doses of intravenous N-acetylcysteine and silibinin. Fourteen patients (61%) underwent extracorporeal elimination method. Ten patients had plasmapheresis, 1 patient had hemoperfusion, and 5 patients had fractionated plasma separation and adsorption. Seven patients who met King&apos;s College Criteria were listed for urgent liver transplantation; one of them died before transplantation. Six patients underwent liver transplantation; the mean waiting time was 6.5 +/- 12.0 days (range, 1-31 days). One patient died 2 months afterward. All 16 patients who did not meet King&apos;s College Criteria and received conservative treatment survived. Conclusion. Our results documented a good prognostic value of standard King&apos;s College Criteria for indication of urgent liver transplantation in acute liver failure caused by Amanita phalloides poisoning. Fractionated plasma separation and adsorption may contribute to low mortality on the waiting list. Intensive care and extracorporeal elimination methods seem to be crucial points of the conservative treatment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Transplantation proceedings

ISSN

0041-1345

e-ISSN

—

Svazek periodika

50

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

192-197

Kód UT WoS článku

000424311600033

EID výsledku v databázi Scopus

2-s2.0-85044275923