The role of free radicals in autophagy regulation: Implications for ageing

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00076568" target="_blank" >RIV/00023001:_____/18:00076568 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.hindawi.com/journals/omcl/2018/2450748/" target="_blank" >https://www.hindawi.com/journals/omcl/2018/2450748/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2018/2450748" target="_blank" >10.1155/2018/2450748</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The role of free radicals in autophagy regulation: Implications for ageing

Popis výsledku v původním jazyce

Reactive oxygen and nitrogen species (ROS and RNS, resp.) have been traditionally perceived solely as detrimental, leading to oxidative damage of biological macromolecules and organelles, cellular demise, and ageing. However, recent data suggest that ROS/RNS also plays an integral role in intracellular signalling and redox homeostasis (redoxtasis), which are necessary for the maintenance of cellular functions. There is a complex relationship between cellular ROS/RNS content and autophagy, which represents one of the major quality control systems in the cell. In this review, we focus on redox signalling and autophagy regulation with a special interest on ageing-associated changes. In the last section, we describe the role of autophagy and redox signalling in the context of Alzheimer&apos;s disease as an example of a prevalent age-related disorder.

Název v anglickém jazyce

The role of free radicals in autophagy regulation: Implications for ageing

Popis výsledku anglicky

Reactive oxygen and nitrogen species (ROS and RNS, resp.) have been traditionally perceived solely as detrimental, leading to oxidative damage of biological macromolecules and organelles, cellular demise, and ageing. However, recent data suggest that ROS/RNS also plays an integral role in intracellular signalling and redox homeostasis (redoxtasis), which are necessary for the maintenance of cellular functions. There is a complex relationship between cellular ROS/RNS content and autophagy, which represents one of the major quality control systems in the cell. In this review, we focus on redox signalling and autophagy regulation with a special interest on ageing-associated changes. In the last section, we describe the role of autophagy and redox signalling in the context of Alzheimer&apos;s disease as an example of a prevalent age-related disorder.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10601 - Cell biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Oxidative medicine and cellular longevity

ISSN

1942-0900

e-ISSN

—

Svazek periodika

2018

Číslo periodika v rámci svazku

February 26

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

19

Strana od-do

"art. no. 2450748"

Kód UT WoS článku

000427184600001

EID výsledku v databázi Scopus

2-s2.0-85048879729