Can point shear wave elastography differentiate focal nodular hyperplasia from hepatocellular adenoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00076942" target="_blank" >RIV/00023001:_____/18:00076942 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcu.22603" target="_blank" >https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcu.22603</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jcu.22603" target="_blank" >10.1002/jcu.22603</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Can point shear wave elastography differentiate focal nodular hyperplasia from hepatocellular adenoma

Popis výsledku v původním jazyce

Purpose Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) are liver tumors that require different management. We assessed the potential of point shear wave elastography (pSWE) to differentiate FNH from HCA and the interobserver and intraobserver reliability of pSWE in the examination of these lesions and of native liver tissue (NLT). Methods The study included 88 patients (65 FNH, 23 HCA). pSWE was performed by two experienced liver sonographers (observers 1 [O1] and 2 [O2]) and acquired within the lesion of interest and NLT. Group differences, optimal cutoff for characterization and interobserver reliability was assessed with Mann-Whitney-U, area under the ROC curce (AUROC) and intraclass correlation coefficient (ICC). Intraobserver reliability in NLT was assessed in 20 healthy subjects using ICC. Results Median stiffness was significantly higher in FNH than in HCA (7.01 kPa vs 4.98 kPa for O1 (P=0.017) and 7.68 kPa vs 6.00 kPa for O2 (P=0.031)). A cutoff point for differentiation between the two entities could not be determined with an AUROC of 0.67 (O1) and 0.69 (O2). Interobserver reliability was good for lesion- stiffness (ICC=0.86) and poor for NLT stiffness (ICC=0.09). In healthy subjects, intraobserver reliability for NLT-stiffness was poor for O1 (ICC=0.23) and moderate for O2 (ICC=0.62). Conclusion This study shows that pSWE cannot reliably differentiate FNH from HCA. Interobserver and intraobserver reliability for pSWE in NLT were insufficient. Interpretation of results gained with this method should be done with great caution.

Název v anglickém jazyce

Can point shear wave elastography differentiate focal nodular hyperplasia from hepatocellular adenoma

Popis výsledku anglicky

Purpose Focal nodular hyperplasia (FNH) and hepatocellular adenoma (HCA) are liver tumors that require different management. We assessed the potential of point shear wave elastography (pSWE) to differentiate FNH from HCA and the interobserver and intraobserver reliability of pSWE in the examination of these lesions and of native liver tissue (NLT). Methods The study included 88 patients (65 FNH, 23 HCA). pSWE was performed by two experienced liver sonographers (observers 1 [O1] and 2 [O2]) and acquired within the lesion of interest and NLT. Group differences, optimal cutoff for characterization and interobserver reliability was assessed with Mann-Whitney-U, area under the ROC curce (AUROC) and intraclass correlation coefficient (ICC). Intraobserver reliability in NLT was assessed in 20 healthy subjects using ICC. Results Median stiffness was significantly higher in FNH than in HCA (7.01 kPa vs 4.98 kPa for O1 (P=0.017) and 7.68 kPa vs 6.00 kPa for O2 (P=0.031)). A cutoff point for differentiation between the two entities could not be determined with an AUROC of 0.67 (O1) and 0.69 (O2). Interobserver reliability was good for lesion- stiffness (ICC=0.86) and poor for NLT stiffness (ICC=0.09). In healthy subjects, intraobserver reliability for NLT-stiffness was poor for O1 (ICC=0.23) and moderate for O2 (ICC=0.62). Conclusion This study shows that pSWE cannot reliably differentiate FNH from HCA. Interobserver and intraobserver reliability for pSWE in NLT were insufficient. Interpretation of results gained with this method should be done with great caution.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of clinical ultrasound : JCU

ISSN

0091-2751

e-ISSN

—

Svazek periodika

46

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

380-385

Kód UT WoS článku

000434419400002

EID výsledku v databázi Scopus

2-s2.0-85046689969&