Reply to Hernandez et al. - GWAS of acute renal graft rejection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00077068" target="_blank" >RIV/00023001:_____/18:00077068 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/pdf/10.1111/ajt.14877" target="_blank" >https://onlinelibrary.wiley.com/doi/pdf/10.1111/ajt.14877</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ajt.14877" target="_blank" >10.1111/ajt.14877</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Reply to Hernandez et al. - GWAS of acute renal graft rejection

Popis výsledku v původním jazyce

We were able to identify and validate the association of 2 genetic loci (CCDC67 and PTPRO) with biopsy-proven T cell–mediated rejection (TCMR). We concentrated our efforts on building a discovery cohort of cases with very low immunological risk. Kidney graft–rejecting cases were all European adults (&gt;18 years of age), not or minimally sensitized, transplanted with a first kidney allograft under calcineurin inhibitors-based immunosuppressive regimen including induction. We ensured that phenotypes were correct and precise. Rejection was of TCMR type and histologically proven. We agree with Hernandez et al that the phenotypic heterogeneity they allowed in their study (cellular and humoral rejections were not distinguished, biopsy was not required, and combined ransplantations were accepted) may have diluted a true genetic association with TCMR in kidney recipients.

Název v anglickém jazyce

Reply to Hernandez et al. - GWAS of acute renal graft rejection

Popis výsledku anglicky

We were able to identify and validate the association of 2 genetic loci (CCDC67 and PTPRO) with biopsy-proven T cell–mediated rejection (TCMR). We concentrated our efforts on building a discovery cohort of cases with very low immunological risk. Kidney graft–rejecting cases were all European adults (&gt;18 years of age), not or minimally sensitized, transplanted with a first kidney allograft under calcineurin inhibitors-based immunosuppressive regimen including induction. We ensured that phenotypes were correct and precise. Rejection was of TCMR type and histologically proven. We agree with Hernandez et al that the phenotypic heterogeneity they allowed in their study (cellular and humoral rejections were not distinguished, biopsy was not required, and combined ransplantations were accepted) may have diluted a true genetic association with TCMR in kidney recipients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30101 - Human genetics

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American journal of transplantation

ISSN

1600-6135

e-ISSN

—

Svazek periodika

18

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

2

Strana od-do

2098-2099

Kód UT WoS článku

000440135200037

EID výsledku v databázi Scopus

2-s2.0-85046812524