Similar microvascular inflammation and tubulointerstitial injury in ABO-incompatible and matched ABO-compatible kidney allografts
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00077096" target="_blank" >RIV/00023001:_____/18:00077096 - isvavai.cz</a>
Výsledek na webu
<a href="https://reader.elsevier.com/reader/sd/pii/S0041134518302148?token=24D2748F382A70F8147726358B60DEF1F3014C7EE29AF8F27C091D2C502414EC3564F7850FE1884177978D9843ADA19E" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0041134518302148?token=24D2748F382A70F8147726358B60DEF1F3014C7EE29AF8F27C091D2C502414EC3564F7850FE1884177978D9843ADA19E</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.transproceed.2018.02.063" target="_blank" >10.1016/j.transproceed.2018.02.063</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Similar microvascular inflammation and tubulointerstitial injury in ABO-incompatible and matched ABO-compatible kidney allografts
Popis výsledku v původním jazyce
ABO-incompatible (ABOi) kidney transplantation represents a viable tool to increase the donor pool for kidney transplantation, however, increased alloimmune response has been debated. The early outcomes of 25 low-risk ABOi kidney transplant recipients were compared with thoroughly matched 50 ABO-compatible (ABOc) ones. The matching process was based on gender and age of recipients and immunologic parameters, such as panel reactive antibodies, number of human leukocyte antigen mismatches, and transplantation era. Three-month protocol kidney graft biopsy Banff scores and 1-year clinical outcomes were compared. Apart from C4d positivity, no statistically significant differences were found regarding the Banff scores between the two groups. Similarly, microvascular inflammation and tubulointerstitial injury revealed no differences either. The eGFR at 3 months and 1 year was similar in both groups. In conclusion, blood group incompatibility yields no additional microvascular and tubulointerstitial graft injury if desensitization protocol was applied to low-risk kidney transplant recipients.
Název v anglickém jazyce
Similar microvascular inflammation and tubulointerstitial injury in ABO-incompatible and matched ABO-compatible kidney allografts
Popis výsledku anglicky
ABO-incompatible (ABOi) kidney transplantation represents a viable tool to increase the donor pool for kidney transplantation, however, increased alloimmune response has been debated. The early outcomes of 25 low-risk ABOi kidney transplant recipients were compared with thoroughly matched 50 ABO-compatible (ABOc) ones. The matching process was based on gender and age of recipients and immunologic parameters, such as panel reactive antibodies, number of human leukocyte antigen mismatches, and transplantation era. Three-month protocol kidney graft biopsy Banff scores and 1-year clinical outcomes were compared. Apart from C4d positivity, no statistically significant differences were found regarding the Banff scores between the two groups. Similarly, microvascular inflammation and tubulointerstitial injury revealed no differences either. The eGFR at 3 months and 1 year was similar in both groups. In conclusion, blood group incompatibility yields no additional microvascular and tubulointerstitial graft injury if desensitization protocol was applied to low-risk kidney transplant recipients.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30212 - Surgery
Návaznosti výsledku
Projekt
<a href="/cs/project/NV15-26865A" target="_blank" >NV15-26865A: Alloreaktivita u transplantací ledvin u žijících dárců</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Transplantation proceedings
ISSN
0041-1345
e-ISSN
—
Svazek periodika
50
Číslo periodika v rámci svazku
5
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
5
Strana od-do
1305-1309
Kód UT WoS článku
000441211400017
EID výsledku v databázi Scopus
2-s2.0-85048459027