Donor and recipient risk factor analysis of inferior postheart transplantation outcome in the era of durable mechanical assist devices

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00077330" target="_blank" >RIV/00023001:_____/18:00077330 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/full/10.1111/ctr.13390" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1111/ctr.13390</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/ctr.13390" target="_blank" >10.1111/ctr.13390</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Donor and recipient risk factor analysis of inferior postheart transplantation outcome in the era of durable mechanical assist devices

Popis výsledku v původním jazyce

The study objective is to quantify the impact of donor and recipient variables on heart transplant survival in recipients with a significant proportion of implanted continuous-flow left ventricular assist devices (LVADs). This is a prospective cohort study of International Society for Heart and Lung Transplantation (ISHLT) Registry that includes all primary heart-alone transplants in adult recipients (January 2005 and June 2013, N=15532, 27% LVADs). Donor and recipient characteristics were assessed for association with death or graft failure within 90days and between 90days and 5years after transplantation. On Cox proportional hazard model donor cause of death other than head trauma (hazard ratio [HR] 1.985, P&lt;0.0001), recipient congenital (HR 2.7555, P&lt;0.0001) and ischemic (HR 1.165, P=0.0383) vs dilated etiology and female donor heart transplanted into male recipient (HR 1.207, P=0.0354) were predictors of death or graft failure within 90days. Between 90days and 5years, donor cigarette use (HR 1.232, P=0.0001), recipient cigarette use (HR 1.193, P=0.0003), diabetes (HR 1.159, P=0.0050), arterial hypertension (HR 1.129, P=0.0115), and ischemic vs dilative cardiomyopathy had an increased probability of death or graft failure.

Název v anglickém jazyce

Donor and recipient risk factor analysis of inferior postheart transplantation outcome in the era of durable mechanical assist devices

Popis výsledku anglicky

The study objective is to quantify the impact of donor and recipient variables on heart transplant survival in recipients with a significant proportion of implanted continuous-flow left ventricular assist devices (LVADs). This is a prospective cohort study of International Society for Heart and Lung Transplantation (ISHLT) Registry that includes all primary heart-alone transplants in adult recipients (January 2005 and June 2013, N=15532, 27% LVADs). Donor and recipient characteristics were assessed for association with death or graft failure within 90days and between 90days and 5years after transplantation. On Cox proportional hazard model donor cause of death other than head trauma (hazard ratio [HR] 1.985, P&lt;0.0001), recipient congenital (HR 2.7555, P&lt;0.0001) and ischemic (HR 1.165, P=0.0383) vs dilated etiology and female donor heart transplanted into male recipient (HR 1.207, P=0.0354) were predictors of death or graft failure within 90days. Between 90days and 5years, donor cigarette use (HR 1.232, P=0.0001), recipient cigarette use (HR 1.193, P=0.0003), diabetes (HR 1.159, P=0.0050), arterial hypertension (HR 1.129, P=0.0115), and ischemic vs dilative cardiomyopathy had an increased probability of death or graft failure.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30213 - Transplantation

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical transplantation

ISSN

0902-0063

e-ISSN

—

Svazek periodika

32

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

"art. no. e13390"

Kód UT WoS článku

000447379000012

EID výsledku v databázi Scopus

2-s2.0-85053479740