Antibody-mediated rejection after liver transplantation - relevance of C1q and C3d-binding antibodies
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F18%3A00077474" target="_blank" >RIV/00023001:_____/18:00077474 - isvavai.cz</a>
Výsledek na webu
<a href="https://onlinelibrary.wiley.com/doi/abs/10.1111/tan.13354" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1111/tan.13354</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/tan.13354" target="_blank" >10.1111/tan.13354</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Antibody-mediated rejection after liver transplantation - relevance of C1q and C3d-binding antibodies
Popis výsledku v původním jazyce
The aim of our study was to evaluate the relevance of complement-binding donor-specific antibodies (DSA) for prediction of antibody-mediated rejection (AMR) after liver transplantation. Sera from 123 liver transplant recipients were retrospectively defined for HLA specificity and complement-fixing activity using the single antigen beads, C1q and C3d techniques. Liver-recipients' sera were tested before transplantation, 3, 6 months and 1 year after transplantation. Patients were followed up for graft survival and rejection incidence for 1 year after transplantation. All patients with pretransplant complement-binding DSA developed severe AMR after transplantation, while three recipients out of four, who produced de novo complement-fixing DSA, developed AMR. Definition of DSA with respect to complement-fixing activity may provide clinically relevant information about the risk of AMR after liver transplantation.
Název v anglickém jazyce
Antibody-mediated rejection after liver transplantation - relevance of C1q and C3d-binding antibodies
Popis výsledku anglicky
The aim of our study was to evaluate the relevance of complement-binding donor-specific antibodies (DSA) for prediction of antibody-mediated rejection (AMR) after liver transplantation. Sera from 123 liver transplant recipients were retrospectively defined for HLA specificity and complement-fixing activity using the single antigen beads, C1q and C3d techniques. Liver-recipients' sera were tested before transplantation, 3, 6 months and 1 year after transplantation. Patients were followed up for graft survival and rejection incidence for 1 year after transplantation. All patients with pretransplant complement-binding DSA developed severe AMR after transplantation, while three recipients out of four, who produced de novo complement-fixing DSA, developed AMR. Definition of DSA with respect to complement-fixing activity may provide clinically relevant information about the risk of AMR after liver transplantation.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30102 - Immunology
Návaznosti výsledku
Projekt
<a href="/cs/project/NV16-27477A" target="_blank" >NV16-27477A: Diagnostika protilátkami zprostředkované rejekce po transplantaci jater</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
HLA
ISSN
2059-2302
e-ISSN
—
Svazek periodika
92
Číslo periodika v rámci svazku
Supplement 2
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
4
Strana od-do
34-37
Kód UT WoS článku
000454095400002
EID výsledku v databázi Scopus
2-s2.0-85058387274