Association between aortic telomere length and cardiac post-transplant allograft function

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078040" target="_blank" >RIV/00023001:_____/19:00078040 - isvavai.cz</a>

Výsledek na webu

<a href="https://reader.elsevier.com/reader/sd/pii/S0167527318356419?token=AF5168725DA3278634727469DE27A2207607D98B1987F57A5BE3504BEC91A4745B6AD9CADABA396479342EC8848EA7A6" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0167527318356419?token=AF5168725DA3278634727469DE27A2207607D98B1987F57A5BE3504BEC91A4745B6AD9CADABA396479342EC8848EA7A6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijcard.2019.05.006" target="_blank" >10.1016/j.ijcard.2019.05.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Association between aortic telomere length and cardiac post-transplant allograft function

Popis výsledku v původním jazyce

Background: In patients having undergone orthotopic heart transplantation, a number of complications exist that are known to be connected to both telomerase activity and telomere length. The aim of this study was to determine how telomere length in aortic DNA correlates with the subsequent post-transplantation development of the patients. Materials and methods: Between 2005 and 2015, we collected aortic samples from 376 heart recipients (age 50.8 +/- 11.8 years) and 383 donors (age 38.6 +/- 12.2 years). Relative telomere length in aortic tissue DNA was determined using quantitative PCR. Results: Shorter telomere length was detected in heart allograft recipients compared to donors (P &lt; 0.0001). Patients suffering acute cellular rejection had significantly shorter telomere length (P &lt; 0.01) than patients without rejection. Shorter telomere length was observed in patients with implanted mechanical circulatory support before heart transplantation (P &lt; 0.03), as well as in subjects with cardiac allograft vasculopathy (P &lt; 0.05). Overall survival time after heart transplantation was associated with shorter donor telomeres (P &lt; 0.004). Conclusions: Telomere length differed between donors and recipients independent of the sex and age of the patients. Our findings suggest a potential new linkage between the aortic telomere length of recipients and post-heart transplant complications. Further studies focusing on epigenetic modifications and gene regulation involved in telomere maintenance in transplanted patients should verify our results. (C) 2019 Elsevier B.V. All rights reserved.

Název v anglickém jazyce

Association between aortic telomere length and cardiac post-transplant allograft function

Popis výsledku anglicky

Background: In patients having undergone orthotopic heart transplantation, a number of complications exist that are known to be connected to both telomerase activity and telomere length. The aim of this study was to determine how telomere length in aortic DNA correlates with the subsequent post-transplantation development of the patients. Materials and methods: Between 2005 and 2015, we collected aortic samples from 376 heart recipients (age 50.8 +/- 11.8 years) and 383 donors (age 38.6 +/- 12.2 years). Relative telomere length in aortic tissue DNA was determined using quantitative PCR. Results: Shorter telomere length was detected in heart allograft recipients compared to donors (P &lt; 0.0001). Patients suffering acute cellular rejection had significantly shorter telomere length (P &lt; 0.01) than patients without rejection. Shorter telomere length was observed in patients with implanted mechanical circulatory support before heart transplantation (P &lt; 0.03), as well as in subjects with cardiac allograft vasculopathy (P &lt; 0.05). Overall survival time after heart transplantation was associated with shorter donor telomeres (P &lt; 0.004). Conclusions: Telomere length differed between donors and recipients independent of the sex and age of the patients. Our findings suggest a potential new linkage between the aortic telomere length of recipients and post-heart transplant complications. Further studies focusing on epigenetic modifications and gene regulation involved in telomere maintenance in transplanted patients should verify our results. (C) 2019 Elsevier B.V. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International journal of cardiology

ISSN

0167-5273

e-ISSN

—

Svazek periodika

290

Číslo periodika v rámci svazku

September 1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

5

Strana od-do

129-133

Kód UT WoS článku

000470826500025

EID výsledku v databázi Scopus

2-s2.0-85065561674