Different acute effects of fructose and glucose administration on hepatic fat content

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078196" target="_blank" >RIV/00023001:_____/19:00078196 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/19:10409248

Výsledek na webu

<a href="https://academic.oup.com/ajcn/article-abstract/109/6/1519/5480599?redirectedFrom=fulltext" target="_blank" >https://academic.oup.com/ajcn/article-abstract/109/6/1519/5480599?redirectedFrom=fulltext</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ajcn/nqy386" target="_blank" >10.1093/ajcn/nqy386</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Different acute effects of fructose and glucose administration on hepatic fat content

Popis výsledku v původním jazyce

Background: Diets rich in fat and added sugars (especially fructose) play an important role in the pathogenesis of nonalcoholic liver disease (NAFLD), but there is only limited information on the acute effects of these nutrients on hepatic fat content (HFC). Objectives: We therefore explored how the administration of high-fat load, glucose, fructose, and combinations thereof affects HFC measured in vivo using proton magnetic resonance spectroscopy (H-1-MRS) in healthy subjects. Methods: Ten healthy nonsteatotic male volunteers (age 38.5 +/- 9.6 y, body mass index [BMI, kg/m(2)] 26.9 +/- 2.7) underwent, in random order, 6 experiments, each lasting 8 h, that included: 1) fasting; 2) a high-fat load (150 g of fat [dairy cream] at time 0); 3) glucose (3 doses of 50 g at 0, 2, and 4 h); 4) a high-fat load with glucose; 5) fructose (3 doses of 50 g at 0, 2, and 4 h); and 6) a high-fat load with fructose. HFC was measured using 1H-MRS prior to test meal administration (before time 0) and at 3 and 6 h. Plasma concentrations of triglycerides, nonesterified fatty acids, glucose, and insulin were monitored throughout each experiment. Results: HFC increased to 119 +/- 19% (P &lt; 0.05) and 117 +/- 17% (P &lt; 0.01) of baseline when subjects consumed a high-fat load alone or a high-fat load with fructose, respectively, but was not affected when glucose was coadministered with a high-fat load. HFC was not affected when subjects had fasted or had consumed repeated doses of fructose. When subjects were administered 3 doses of glucose, HFC dropped to 85 +/- 13% (P &lt; 0.05) of baseline. Conclusions: Our results demonstrate that fructose and glucose have a different immediate impact on HFC in humans in vivo.

Název v anglickém jazyce

Different acute effects of fructose and glucose administration on hepatic fat content

Popis výsledku anglicky

Background: Diets rich in fat and added sugars (especially fructose) play an important role in the pathogenesis of nonalcoholic liver disease (NAFLD), but there is only limited information on the acute effects of these nutrients on hepatic fat content (HFC). Objectives: We therefore explored how the administration of high-fat load, glucose, fructose, and combinations thereof affects HFC measured in vivo using proton magnetic resonance spectroscopy (H-1-MRS) in healthy subjects. Methods: Ten healthy nonsteatotic male volunteers (age 38.5 +/- 9.6 y, body mass index [BMI, kg/m(2)] 26.9 +/- 2.7) underwent, in random order, 6 experiments, each lasting 8 h, that included: 1) fasting; 2) a high-fat load (150 g of fat [dairy cream] at time 0); 3) glucose (3 doses of 50 g at 0, 2, and 4 h); 4) a high-fat load with glucose; 5) fructose (3 doses of 50 g at 0, 2, and 4 h); and 6) a high-fat load with fructose. HFC was measured using 1H-MRS prior to test meal administration (before time 0) and at 3 and 6 h. Plasma concentrations of triglycerides, nonesterified fatty acids, glucose, and insulin were monitored throughout each experiment. Results: HFC increased to 119 +/- 19% (P &lt; 0.05) and 117 +/- 17% (P &lt; 0.01) of baseline when subjects consumed a high-fat load alone or a high-fat load with fructose, respectively, but was not affected when glucose was coadministered with a high-fat load. HFC was not affected when subjects had fasted or had consumed repeated doses of fructose. When subjects were administered 3 doses of glucose, HFC dropped to 85 +/- 13% (P &lt; 0.05) of baseline. Conclusions: Our results demonstrate that fructose and glucose have a different immediate impact on HFC in humans in vivo.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

<a href="/cs/project/NV16-28427A" target="_blank" >NV16-28427A: Monitorování dynamiky metabolismu triglyceridů v játrech metodami MRI</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American journal of clinical nutrition

ISSN

0002-9165

e-ISSN

—

Svazek periodika

109

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

1519-1526

Kód UT WoS článku

000478066900005

EID výsledku v databázi Scopus

2-s2.0-85067278889