Abdominal aortic aneurysm as an IgG4-related disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078266" target="_blank" >RIV/00023001:_____/19:00078266 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023884:_____/19:00008167

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/pdf/10.1111/cei.13307" target="_blank" >https://onlinelibrary.wiley.com/doi/pdf/10.1111/cei.13307</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/cei.13307" target="_blank" >10.1111/cei.13307</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Abdominal aortic aneurysm as an IgG4-related disease

Popis výsledku v původním jazyce

The objectives of this study were to evaluate patients with aortic abdominal aneurysm (AAA) with regard to immunoglobulin (Ig)G4-related disease (IgG4-RD). IgG4-RD represents a recently defined condition comprised of a collection of disorders characterized by IgG4 hypergammaglobulinemia, the presence of IgG4-positive plasma cells in organs affected with fibrotic or sclerotizing changes and typical histopathological features. It was identified as a possible cause of vasculitis in large vessels. Studies have been published on a possible association between inflammatory aortic or cardiovascular disease and IgG4-RD. We examined 114 patients with AAA requiring surgery in order to identify findings which are characteristic of IgG4-RD. Aneurysm samples from seven patients showed histopathological features consistent with IgG4-RD and the presence of IgG4(+) plasma cells. Only two of these seven patients showed elevated IgG4 serum levels higher 1 center dot 35 g/l. In five of the patients, the concentration of serum IgG4 was lower than 1 center dot 20 g/l, with the number of IgG4(+) plasma cells being higher than 50/high-power field. These findings were consistent with AAA being a heterogeneous group of inflammatory diseases with different pathogenesis.

Název v anglickém jazyce

Abdominal aortic aneurysm as an IgG4-related disease

Popis výsledku anglicky

The objectives of this study were to evaluate patients with aortic abdominal aneurysm (AAA) with regard to immunoglobulin (Ig)G4-related disease (IgG4-RD). IgG4-RD represents a recently defined condition comprised of a collection of disorders characterized by IgG4 hypergammaglobulinemia, the presence of IgG4-positive plasma cells in organs affected with fibrotic or sclerotizing changes and typical histopathological features. It was identified as a possible cause of vasculitis in large vessels. Studies have been published on a possible association between inflammatory aortic or cardiovascular disease and IgG4-RD. We examined 114 patients with AAA requiring surgery in order to identify findings which are characteristic of IgG4-RD. Aneurysm samples from seven patients showed histopathological features consistent with IgG4-RD and the presence of IgG4(+) plasma cells. Only two of these seven patients showed elevated IgG4 serum levels higher 1 center dot 35 g/l. In five of the patients, the concentration of serum IgG4 was lower than 1 center dot 20 g/l, with the number of IgG4(+) plasma cells being higher than 50/high-power field. These findings were consistent with AAA being a heterogeneous group of inflammatory diseases with different pathogenesis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical and experimental immunology

ISSN

0009-9104

e-ISSN

—

Svazek periodika

197

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

361-365

Kód UT WoS článku

000481437700010

EID výsledku v databázi Scopus

2-s2.0-85070600185