Vše

Co hledáte?

Vše
Projekty
Výsledky výzkumu
Subjekty

Rychlé hledání

  • Projekty podpořené TA ČR
  • Významné projekty
  • Projekty s nejvyšší státní podporou
  • Aktuálně běžící projekty

Chytré vyhledávání

  • Takto najdu konkrétní +slovo
  • Takto z výsledků -slovo zcela vynechám
  • “Takto můžu najít celou frázi”

The relationship of mitochondrial dysfunction and the development of insulin resistance in Cushing's syndrome

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078342" target="_blank" >RIV/00023001:_____/19:00078342 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00216208:11110/19:10403093 RIV/00023728:_____/19:N0000078 RIV/00064165:_____/19:10403093

  • Výsledek na webu

    <a href="https://www.dovepress.com/the-relationship-of-mitochondrial-dysfunction-and-the-development-of-i-peer-reviewed-fulltext-article-DMSO" target="_blank" >https://www.dovepress.com/the-relationship-of-mitochondrial-dysfunction-and-the-development-of-i-peer-reviewed-fulltext-article-DMSO</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2147/DMSO.S209095" target="_blank" >10.2147/DMSO.S209095</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    The relationship of mitochondrial dysfunction and the development of insulin resistance in Cushing's syndrome

  • Popis výsledku v původním jazyce

    Purpose: Cushing&apos;s syndrome is characterized by metabolic disturbances including insulin resistance. Mitochondrial dysfunction is one pathogenic factor in the development of insulin resistance in patients with obesity. We explored whether mitochondrial dysfunction correlates with insulin resistance and other metabolic complications. Patients and methods: We investigated the changes of mRNA expression of genes encoding selected subunits of oxidative phosphorylation system (OXPHOS), pyruvate dehydrogenase (PDH) and citrate synthase (CS) in subcutaneous adipose tissue (SCAT) and peripheral monocytes (PM) and mitochondrial enzyme activity in platelets of 24 patients with active Cushing&apos;s syndrome and in 9 of them after successful treatment and 22 healthy control subjects. Results: Patients with active Cushing&apos;s syndrome had significantly increased body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR) and serum lipids relative to the control group. The expression of all investigated genes for selected mitochondrial proteins was decreased in SCAT in patients with active Cushing&apos;s syndrome and remained decreased after successful treatment. The expression of most tested genes in SCAT correlated inversely with BMI and HOMA-IR. The expression of genes encoding selected OXPHOS subunits and CS was increased in PM in patients with active Cushing&apos;s syndrome with a tendency to decrease toward normal levels after cure. Patients with active Cushing&apos;s syndrome showed increased enzyme activity of complex I (NQR) in platelets. Conclusion: Mitochondrial function in SCAT in patients with Cushing&apos;s syndrome is impaired and only slightly affected by its treatment which may reflect ongoing metabolic disturbances even after successful treatment of Cushing&apos;s syndrome.

  • Název v anglickém jazyce

    The relationship of mitochondrial dysfunction and the development of insulin resistance in Cushing's syndrome

  • Popis výsledku anglicky

    Purpose: Cushing&apos;s syndrome is characterized by metabolic disturbances including insulin resistance. Mitochondrial dysfunction is one pathogenic factor in the development of insulin resistance in patients with obesity. We explored whether mitochondrial dysfunction correlates with insulin resistance and other metabolic complications. Patients and methods: We investigated the changes of mRNA expression of genes encoding selected subunits of oxidative phosphorylation system (OXPHOS), pyruvate dehydrogenase (PDH) and citrate synthase (CS) in subcutaneous adipose tissue (SCAT) and peripheral monocytes (PM) and mitochondrial enzyme activity in platelets of 24 patients with active Cushing&apos;s syndrome and in 9 of them after successful treatment and 22 healthy control subjects. Results: Patients with active Cushing&apos;s syndrome had significantly increased body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR) and serum lipids relative to the control group. The expression of all investigated genes for selected mitochondrial proteins was decreased in SCAT in patients with active Cushing&apos;s syndrome and remained decreased after successful treatment. The expression of most tested genes in SCAT correlated inversely with BMI and HOMA-IR. The expression of genes encoding selected OXPHOS subunits and CS was increased in PM in patients with active Cushing&apos;s syndrome with a tendency to decrease toward normal levels after cure. Patients with active Cushing&apos;s syndrome showed increased enzyme activity of complex I (NQR) in platelets. Conclusion: Mitochondrial function in SCAT in patients with Cushing&apos;s syndrome is impaired and only slightly affected by its treatment which may reflect ongoing metabolic disturbances even after successful treatment of Cushing&apos;s syndrome.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30202 - Endocrinology and metabolism (including diabetes, hormones)

Návaznosti výsledku

  • Projekt

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2019

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Diabetes, metabolic syndrome and obesity: Targets and therapy

  • ISSN

    1178-7007

  • e-ISSN

  • Svazek periodika

    12

  • Číslo periodika v rámci svazku

    2019

  • Stát vydavatele periodika

    NZ - Nový Zéland

  • Počet stran výsledku

    13

  • Strana od-do

    1459-1471

  • Kód UT WoS článku

    000483444700001

  • EID výsledku v databázi Scopus

    2-s2.0-85073344340