Accuracy of colon capsule endoscopy for colorectal neoplasia detection in individuals referred for a screening colonoscopy
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078367" target="_blank" >RIV/00023001:_____/19:00078367 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11110/19:10396706 RIV/00179906:_____/19:10396706 RIV/00216224:14110/19:00108525 RIV/00216208:11150/19:10396706 a 2 dalších
Výsledek na webu
<a href="http://downloads.hindawi.com/journals/grp/2019/5975438.pdf" target="_blank" >http://downloads.hindawi.com/journals/grp/2019/5975438.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2019/5975438" target="_blank" >10.1155/2019/5975438</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Accuracy of colon capsule endoscopy for colorectal neoplasia detection in individuals referred for a screening colonoscopy
Popis výsledku v původním jazyce
Backround. Capsule colonoscopy might present an alternative to colonoscopy for colorectal neoplasia screening. Aim. To assess the accuracy of second-generation capsule colonoscopy (CCE2) for colorectal neoplasia detection compared with conventional colonoscopy (CC). Methods. From 2011-2015, we performed a multicenter, prospective, cross-over study evaluating the use of CCE2 as a possible colorectal cancer (CRC) screening test based on the assessment of the method's characteristics (accuracy) and safety and patient acceptance of the routine. Enrolled participants fulfilled the CRC screening population criteria if they were asymptomatic, were older than 50, and had no personal or familial history of colorectal neoplasia. The primary outcome was accuracy for the detection of polyps >= 6 mm. Secondary outcomes were accuracy for all polyps, polyps >= 10 mm, adenomas >= 10 mm, and cancers, the quality of bowel cleansing, safety, and CCE2 acceptability by the screening population. Results. A total of 236 individuals were examined; 11 patients (5%) were excluded. Therefore, 225 subjects (95%) were considered in the intention-to-screen (ITS) group. A total of 201 patients (89%) completed both examinations successfully (per protocol group). In the ITS group, polyps were diagnosed during CC in 114 subjects (51%); polyps >= 6 mm, polyps >= 10 mm, and adenomas >= 10 mm were diagnosed in 34 (15%), 16 (7%), and 11 (5%) patients, respectively. The sensitivity of CCE2 for polyps >= 6 mm, polyps >= 10 mm, and adenomas >= 10 mm was 79% (95% confidence interval (CI): 62-91%), 88% (95% CI: 62-98%), and 100% (95% CI: 72-100%), respectively. Conclusion. Second-generation capsule colonoscopy is a safe, noninvasive, and sensitive method for colorectal neoplasia detection although CC remains the preferred method for considerable proportion of subjects. CCE2 may therefore be accepted as the primary screening test for colorectal cancer screening.
Název v anglickém jazyce
Accuracy of colon capsule endoscopy for colorectal neoplasia detection in individuals referred for a screening colonoscopy
Popis výsledku anglicky
Backround. Capsule colonoscopy might present an alternative to colonoscopy for colorectal neoplasia screening. Aim. To assess the accuracy of second-generation capsule colonoscopy (CCE2) for colorectal neoplasia detection compared with conventional colonoscopy (CC). Methods. From 2011-2015, we performed a multicenter, prospective, cross-over study evaluating the use of CCE2 as a possible colorectal cancer (CRC) screening test based on the assessment of the method's characteristics (accuracy) and safety and patient acceptance of the routine. Enrolled participants fulfilled the CRC screening population criteria if they were asymptomatic, were older than 50, and had no personal or familial history of colorectal neoplasia. The primary outcome was accuracy for the detection of polyps >= 6 mm. Secondary outcomes were accuracy for all polyps, polyps >= 10 mm, adenomas >= 10 mm, and cancers, the quality of bowel cleansing, safety, and CCE2 acceptability by the screening population. Results. A total of 236 individuals were examined; 11 patients (5%) were excluded. Therefore, 225 subjects (95%) were considered in the intention-to-screen (ITS) group. A total of 201 patients (89%) completed both examinations successfully (per protocol group). In the ITS group, polyps were diagnosed during CC in 114 subjects (51%); polyps >= 6 mm, polyps >= 10 mm, and adenomas >= 10 mm were diagnosed in 34 (15%), 16 (7%), and 11 (5%) patients, respectively. The sensitivity of CCE2 for polyps >= 6 mm, polyps >= 10 mm, and adenomas >= 10 mm was 79% (95% confidence interval (CI): 62-91%), 88% (95% CI: 62-98%), and 100% (95% CI: 72-100%), respectively. Conclusion. Second-generation capsule colonoscopy is a safe, noninvasive, and sensitive method for colorectal neoplasia detection although CC remains the preferred method for considerable proportion of subjects. CCE2 may therefore be accepted as the primary screening test for colorectal cancer screening.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30219 - Gastroenterology and hepatology
Návaznosti výsledku
Projekt
<a href="/cs/project/NV16-29614A" target="_blank" >NV16-29614A: Porovnání účinnosti kolonické kapslové endoskopie a optické kolonoskopie u osob s pozitivním imunochemickým testem na okultní krvácení do stolice</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Gastroenterology research and practice [online]
ISSN
1687-6121
e-ISSN
—
Svazek periodika
2019
Číslo periodika v rámci svazku
September 3
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
8
Strana od-do
"art. no. 5975438"
Kód UT WoS článku
000486404300001
EID výsledku v databázi Scopus
2-s2.0-85072396755