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Accuracy of colon capsule endoscopy for colorectal neoplasia detection in individuals referred for a screening colonoscopy

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078367" target="_blank" >RIV/00023001:_____/19:00078367 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00216208:11110/19:10396706 RIV/00179906:_____/19:10396706 RIV/00216224:14110/19:00108525 RIV/00216208:11150/19:10396706 a 2 dalších

  • Výsledek na webu

    <a href="http://downloads.hindawi.com/journals/grp/2019/5975438.pdf" target="_blank" >http://downloads.hindawi.com/journals/grp/2019/5975438.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1155/2019/5975438" target="_blank" >10.1155/2019/5975438</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Accuracy of colon capsule endoscopy for colorectal neoplasia detection in individuals referred for a screening colonoscopy

  • Popis výsledku v původním jazyce

    Backround. Capsule colonoscopy might present an alternative to colonoscopy for colorectal neoplasia screening. Aim. To assess the accuracy of second-generation capsule colonoscopy (CCE2) for colorectal neoplasia detection compared with conventional colonoscopy (CC). Methods. From 2011-2015, we performed a multicenter, prospective, cross-over study evaluating the use of CCE2 as a possible colorectal cancer (CRC) screening test based on the assessment of the method&apos;s characteristics (accuracy) and safety and patient acceptance of the routine. Enrolled participants fulfilled the CRC screening population criteria if they were asymptomatic, were older than 50, and had no personal or familial history of colorectal neoplasia. The primary outcome was accuracy for the detection of polyps &gt;= 6 mm. Secondary outcomes were accuracy for all polyps, polyps &gt;= 10 mm, adenomas &gt;= 10 mm, and cancers, the quality of bowel cleansing, safety, and CCE2 acceptability by the screening population. Results. A total of 236 individuals were examined; 11 patients (5%) were excluded. Therefore, 225 subjects (95%) were considered in the intention-to-screen (ITS) group. A total of 201 patients (89%) completed both examinations successfully (per protocol group). In the ITS group, polyps were diagnosed during CC in 114 subjects (51%); polyps &gt;= 6 mm, polyps &gt;= 10 mm, and adenomas &gt;= 10 mm were diagnosed in 34 (15%), 16 (7%), and 11 (5%) patients, respectively. The sensitivity of CCE2 for polyps &gt;= 6 mm, polyps &gt;= 10 mm, and adenomas &gt;= 10 mm was 79% (95% confidence interval (CI): 62-91%), 88% (95% CI: 62-98%), and 100% (95% CI: 72-100%), respectively. Conclusion. Second-generation capsule colonoscopy is a safe, noninvasive, and sensitive method for colorectal neoplasia detection although CC remains the preferred method for considerable proportion of subjects. CCE2 may therefore be accepted as the primary screening test for colorectal cancer screening.

  • Název v anglickém jazyce

    Accuracy of colon capsule endoscopy for colorectal neoplasia detection in individuals referred for a screening colonoscopy

  • Popis výsledku anglicky

    Backround. Capsule colonoscopy might present an alternative to colonoscopy for colorectal neoplasia screening. Aim. To assess the accuracy of second-generation capsule colonoscopy (CCE2) for colorectal neoplasia detection compared with conventional colonoscopy (CC). Methods. From 2011-2015, we performed a multicenter, prospective, cross-over study evaluating the use of CCE2 as a possible colorectal cancer (CRC) screening test based on the assessment of the method&apos;s characteristics (accuracy) and safety and patient acceptance of the routine. Enrolled participants fulfilled the CRC screening population criteria if they were asymptomatic, were older than 50, and had no personal or familial history of colorectal neoplasia. The primary outcome was accuracy for the detection of polyps &gt;= 6 mm. Secondary outcomes were accuracy for all polyps, polyps &gt;= 10 mm, adenomas &gt;= 10 mm, and cancers, the quality of bowel cleansing, safety, and CCE2 acceptability by the screening population. Results. A total of 236 individuals were examined; 11 patients (5%) were excluded. Therefore, 225 subjects (95%) were considered in the intention-to-screen (ITS) group. A total of 201 patients (89%) completed both examinations successfully (per protocol group). In the ITS group, polyps were diagnosed during CC in 114 subjects (51%); polyps &gt;= 6 mm, polyps &gt;= 10 mm, and adenomas &gt;= 10 mm were diagnosed in 34 (15%), 16 (7%), and 11 (5%) patients, respectively. The sensitivity of CCE2 for polyps &gt;= 6 mm, polyps &gt;= 10 mm, and adenomas &gt;= 10 mm was 79% (95% confidence interval (CI): 62-91%), 88% (95% CI: 62-98%), and 100% (95% CI: 72-100%), respectively. Conclusion. Second-generation capsule colonoscopy is a safe, noninvasive, and sensitive method for colorectal neoplasia detection although CC remains the preferred method for considerable proportion of subjects. CCE2 may therefore be accepted as the primary screening test for colorectal cancer screening.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30219 - Gastroenterology and hepatology

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/NV16-29614A" target="_blank" >NV16-29614A: Porovnání účinnosti kolonické kapslové endoskopie a optické kolonoskopie u osob s pozitivním imunochemickým testem na okultní krvácení do stolice</a><br>

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2019

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Gastroenterology research and practice [online]

  • ISSN

    1687-6121

  • e-ISSN

  • Svazek periodika

    2019

  • Číslo periodika v rámci svazku

    September 3

  • Stát vydavatele periodika

    GB - Spojené království Velké Británie a Severního Irska

  • Počet stran výsledku

    8

  • Strana od-do

    "art. no. 5975438"

  • Kód UT WoS článku

    000486404300001

  • EID výsledku v databázi Scopus

    2-s2.0-85072396755