Non-traditional administration of remifentanil in an experimental setting

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F19%3A00078695" target="_blank" >RIV/00023001:_____/19:00078695 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/19:43919124 RIV/00064173:_____/19:N0000142

Výsledek na webu

<a href="http://www.biomed.cas.cz/physiolres/pdf/68/68_S97.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/68/68_S97.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33549/physiolres.934330" target="_blank" >10.33549/physiolres.934330</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Non-traditional administration of remifentanil in an experimental setting

Popis výsledku v původním jazyce

Remifentanil is ultrashort-acting opioid with a unique pharmacokinetic profile. It is used exclusively intravenously. While considering its rapid onset of action and other pharmacokinetic properties, we decided to assess its effects following administration via non-traditional routes. Rabbits (n=10 per each group) were randomized into six groups: remifentanil 1 mu g/kg and 3 mu g/kg IM, 5.0 and 10.0 mu g/kg conjunctivally, and 10 mu g/kg and 25.0 mu g/kg intranasally. Sedating effects were assessed via a loss of the righting reflex. Secondary, mean arterial blood pressure, arterial oxygen saturation of hemoglobin, and pulse rate was monitored in all rabbits. Non-traditional routes of administration were shown to provide a rapid onset of action as well as fast recovery. Importantly, the administration of remifentanil did not result in any deterioration of cardiovascular functions.

Název v anglickém jazyce

Non-traditional administration of remifentanil in an experimental setting

Popis výsledku anglicky

Remifentanil is ultrashort-acting opioid with a unique pharmacokinetic profile. It is used exclusively intravenously. While considering its rapid onset of action and other pharmacokinetic properties, we decided to assess its effects following administration via non-traditional routes. Rabbits (n=10 per each group) were randomized into six groups: remifentanil 1 mu g/kg and 3 mu g/kg IM, 5.0 and 10.0 mu g/kg conjunctivally, and 10 mu g/kg and 25.0 mu g/kg intranasally. Sedating effects were assessed via a loss of the righting reflex. Secondary, mean arterial blood pressure, arterial oxygen saturation of hemoglobin, and pulse rate was monitored in all rabbits. Non-traditional routes of administration were shown to provide a rapid onset of action as well as fast recovery. Importantly, the administration of remifentanil did not result in any deterioration of cardiovascular functions.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30223 - Anaesthesiology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological research

ISSN

0862-8408

e-ISSN

—

Svazek periodika

68

Číslo periodika v rámci svazku

Suppl. 1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

"S97"-"S103"

Kód UT WoS článku

000499085100011

EID výsledku v databázi Scopus

2-s2.0-85075530461