Copy number of the mitochondrial DNA of leucocytes as an aging marker and risk factors for the development of age-related diseases in humans

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F20%3A00079574" target="_blank" >RIV/00023001:_____/20:00079574 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/content/pdf/10.1134%2FS2079057020010129.pdf" target="_blank" >https://link.springer.com/content/pdf/10.1134%2FS2079057020010129.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1134/S2079057020010129" target="_blank" >10.1134/S2079057020010129</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Copy number of the mitochondrial DNA of leucocytes as an aging marker and risk factors for the development of age-related diseases in humans

Popis výsledku v původním jazyce

The mitochondrial DNA (mtDNA) copy number was analyzed via quantitative real-time PCR. A random subset of 996 people was studied (437 men with an average age of 67.3 +/- 7.2 years and 559 women with an average age of 67.6 +/- 7.1 years). They were selected from a population cohort of 9360 people who were initially examined in the international HAPIEE project (2003-2005, initial age of 45-69 years) in Novosibirsk. The participants were reexamined after 12 years in 2015-2017. The average relative mtDNA copy number in women was significantly higher than in men, regardless of age and smoking status, p = 0.001. The relative mtDNA copy number of blood leukocytes negatively correlated with age in men (p = 0.005) and women (p &lt; 0.001). In the age-standardized analysis, the mtDNA copy number was negatively associated with waist and hip size and heart rate in people of both genders. Associations with some other indicators depend on gender. In women, the mtDNA copy number was negatively associated with the atherogenicity level, body mass indices, and blood glucose level and positively associated with HDL cholesterol. In men, the mtDNA copy number is positively related to the level of physical activity. Regardless of age, the average relative mtDNA copy number in peripheral blood leukocytes was higher in nonsmoking men than in smokers (p = 0.003). The mtDNA copy number was lower in women with diabetes mellitus than in women without it (p = 0.005). In both genders, people with an initial history of arterial hypertension had a lower mtDNA copy number in peripheral blood leukocytes after 12 years of observation than normotonics (p = 0.05). These results broadly support the hypothesis that the mtDNA copy number may act as a biomarker of age.

Název v anglickém jazyce

Copy number of the mitochondrial DNA of leucocytes as an aging marker and risk factors for the development of age-related diseases in humans

Popis výsledku anglicky

The mitochondrial DNA (mtDNA) copy number was analyzed via quantitative real-time PCR. A random subset of 996 people was studied (437 men with an average age of 67.3 +/- 7.2 years and 559 women with an average age of 67.6 +/- 7.1 years). They were selected from a population cohort of 9360 people who were initially examined in the international HAPIEE project (2003-2005, initial age of 45-69 years) in Novosibirsk. The participants were reexamined after 12 years in 2015-2017. The average relative mtDNA copy number in women was significantly higher than in men, regardless of age and smoking status, p = 0.001. The relative mtDNA copy number of blood leukocytes negatively correlated with age in men (p = 0.005) and women (p &lt; 0.001). In the age-standardized analysis, the mtDNA copy number was negatively associated with waist and hip size and heart rate in people of both genders. Associations with some other indicators depend on gender. In women, the mtDNA copy number was negatively associated with the atherogenicity level, body mass indices, and blood glucose level and positively associated with HDL cholesterol. In men, the mtDNA copy number is positively related to the level of physical activity. Regardless of age, the average relative mtDNA copy number in peripheral blood leukocytes was higher in nonsmoking men than in smokers (p = 0.003). The mtDNA copy number was lower in women with diabetes mellitus than in women without it (p = 0.005). In both genders, people with an initial history of arterial hypertension had a lower mtDNA copy number in peripheral blood leukocytes after 12 years of observation than normotonics (p = 0.05). These results broadly support the hypothesis that the mtDNA copy number may act as a biomarker of age.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30227 - Geriatrics and gerontology

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Advances in Gerontology

ISSN

2079-0570

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

RU - Ruská federace

Počet stran výsledku

8

Strana od-do

1-8

Kód UT WoS článku

000524502500001

EID výsledku v databázi Scopus

2-s2.0-85083094721