Multiparametric quantitative brain MRI in neurological and hepatic forms of Wilson's disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F20%3A00079647" target="_blank" >RIV/00023001:_____/20:00079647 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/20:10411377 RIV/00064165:_____/20:10411377

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmri.26984" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmri.26984</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jmri.26984" target="_blank" >10.1002/jmri.26984</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Multiparametric quantitative brain MRI in neurological and hepatic forms of Wilson's disease

Popis výsledku v původním jazyce

BACKGROUND: In Wilson&apos;s disease (WD), demyelination, rarefaction, gliosis, and iron accumulation in the deep gray matter cause opposing effects on T(2) -weighted MR signal. However, the degree and interplay of these changes in chronically treated WD patients has not been quantitatively studied. PURPOSE: To compare differences in brain multiparametric mapping between controls and chronically treated WD patients with neurological (neuro-WD) and hepatic (hep-WD) forms to infer the nature of residual WD neuropathology. STUDY TYPE: Cross-sectional. POPULATION/SUBJECTS: Thirty-eight WD patients (28 neuro-WD, 10 hep-WD); 26 healthy controls. FIELD STRENGTH/SEQUENCE: 3.0T: susceptibility, T(2) *, T(2) , T(1) relaxometry; 1.5T: T(2) , T(1) relaxometry. ASSESSMENT: The following 3D regions of interest (ROIs) were manually segmented: globus pallidus, putamen, caudate nucleus, and thalamus. Mean bulk magnetic susceptibility, T(2) *, T(2) , and T(1) relaxation times were calculated for each ROI. STATISTICAL TESTS: The effect of group (neuro-WD, hep-WD, controls) and age was assessed using a generalized least squares model with different variance for each ROI and quantitative parameter. A general linear hypothesis test with Tukey adjustment was used for post-hoc between-group analysis; P &lt; 0.05 was considered significant. RESULTS: Susceptibility values were higher in all ROIs in neuro-WD compared to controls and hep-WD (P &lt; 0.001). In basal ganglia, lower T(2) and T(2) * were found in neuro-WD compared to controls (P &lt; 0.01) and hep-WD (P &lt; 0.05) at 3.0T. Much smaller intergroup differences for T(2) in basal ganglia were observed at 1.5T compared to 3.0T. In the thalamus, increased susceptibility in neuro-WD was accompanied by increased T(1) at both field strengths (P &lt; 0.001 to both groups), and an increased T(2) at 1.5T only (P &lt; 0.001 to both groups). DATA CONCLUSION: We observed significant residual brain MRI abnormalities in neuro-WD but not in hep-WD patients on chronic anticopper treatment. Patterns of changes were suggestive of iron accumulation in the basal ganglia and demyelination in the thalamus; 3.0T was more sensitive for detection of the former and 1.5T of the latter abnormality. LEVEL OF EVIDENCE: 2 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2020;51:1829-1835.

Název v anglickém jazyce

Multiparametric quantitative brain MRI in neurological and hepatic forms of Wilson's disease

Popis výsledku anglicky

BACKGROUND: In Wilson&apos;s disease (WD), demyelination, rarefaction, gliosis, and iron accumulation in the deep gray matter cause opposing effects on T(2) -weighted MR signal. However, the degree and interplay of these changes in chronically treated WD patients has not been quantitatively studied. PURPOSE: To compare differences in brain multiparametric mapping between controls and chronically treated WD patients with neurological (neuro-WD) and hepatic (hep-WD) forms to infer the nature of residual WD neuropathology. STUDY TYPE: Cross-sectional. POPULATION/SUBJECTS: Thirty-eight WD patients (28 neuro-WD, 10 hep-WD); 26 healthy controls. FIELD STRENGTH/SEQUENCE: 3.0T: susceptibility, T(2) *, T(2) , T(1) relaxometry; 1.5T: T(2) , T(1) relaxometry. ASSESSMENT: The following 3D regions of interest (ROIs) were manually segmented: globus pallidus, putamen, caudate nucleus, and thalamus. Mean bulk magnetic susceptibility, T(2) *, T(2) , and T(1) relaxation times were calculated for each ROI. STATISTICAL TESTS: The effect of group (neuro-WD, hep-WD, controls) and age was assessed using a generalized least squares model with different variance for each ROI and quantitative parameter. A general linear hypothesis test with Tukey adjustment was used for post-hoc between-group analysis; P &lt; 0.05 was considered significant. RESULTS: Susceptibility values were higher in all ROIs in neuro-WD compared to controls and hep-WD (P &lt; 0.001). In basal ganglia, lower T(2) and T(2) * were found in neuro-WD compared to controls (P &lt; 0.01) and hep-WD (P &lt; 0.05) at 3.0T. Much smaller intergroup differences for T(2) in basal ganglia were observed at 1.5T compared to 3.0T. In the thalamus, increased susceptibility in neuro-WD was accompanied by increased T(1) at both field strengths (P &lt; 0.001 to both groups), and an increased T(2) at 1.5T only (P &lt; 0.001 to both groups). DATA CONCLUSION: We observed significant residual brain MRI abnormalities in neuro-WD but not in hep-WD patients on chronic anticopper treatment. Patterns of changes were suggestive of iron accumulation in the basal ganglia and demyelination in the thalamus; 3.0T was more sensitive for detection of the former and 1.5T of the latter abnormality. LEVEL OF EVIDENCE: 2 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2020;51:1829-1835.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/NV15-25602A" target="_blank" >NV15-25602A: Biomarkery progrese a terapeutické odpovědi u neurodegenerativních onemocnění</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of magnetic resonance imaging

ISSN

1053-1807

e-ISSN

—

Svazek periodika

51

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

1829-1835

Kód UT WoS článku

000495543200001

EID výsledku v databázi Scopus

2-s2.0-85075009186