Long-Term Outcome of Patients With Congenital Heart Disease Undergoing Cardiac Resynchronization Therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00080940" target="_blank" >RIV/00023001:_____/21:00080940 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023884:_____/21:00008781 RIV/00064203:_____/21:10425805 RIV/00216208:11130/21:10425805

Výsledek na webu

<a href="https://www.ahajournals.org/doi/pdf/10.1161/JAHA.120.018302" target="_blank" >https://www.ahajournals.org/doi/pdf/10.1161/JAHA.120.018302</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1161/JAHA.120.018302" target="_blank" >10.1161/JAHA.120.018302</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Long-Term Outcome of Patients With Congenital Heart Disease Undergoing Cardiac Resynchronization Therapy

Popis výsledku v původním jazyce

Background Cardiac resynchronization therapy (CRT) is rarely used in patients with congenital heart disease, and reported follow-up is short. We sought to evaluate long-term impact of CRT in a single-center cohort of patients with congenital heart disease. Methods and Results Thirty-two consecutive patients with structural congenital heart disease (N=30) or congenital atrioventricular block (N=2), aged median of 12.9 years at CRT with pacing capability device implantation, were followed up for a median of 8.7 years. CRT response was defined as an increase in systemic ventricular ejection fraction or fractional area of change by &gt;10 units and improved or unchanged New York Heart Association class. Freedom from cardiovascular death, heart failure hospitalization, or new transplant listing was 92.6% and 83.2% at 5 and 10 years, respectively. Freedom from CRT complications, leading to surgical system revision (elective generator replacement excluded) or therapy termination, was 82.7% and 72.2% at 5 and 10 years, respectively. The overall probability of an uneventful therapy continuation was 76.3% and 58.8% at 5 and 10 years, respectively. There was a significant increase in ejection fraction/fractional area of change (P&lt;0.001) mainly attributable to patients with systemic left ventricle (P=0.002) and decrease in systemic ventricular end-diastolic dimensions (P&lt;0.05) after CRT. New York Heart Association functional class improved from a median 2.0 to 1.25 (P&lt;0.001). Long-term CRT response was present in 54.8% of patients at last follow-up and was more frequent in systemic left ventricle (P&lt;0.001). Conclusions CRT in patients with congenital heart disease was associated with acceptable survival and long-term response in approximate to 50% of patients. Probability of an uneventful CRT continuation was modest.

Název v anglickém jazyce

Long-Term Outcome of Patients With Congenital Heart Disease Undergoing Cardiac Resynchronization Therapy

Popis výsledku anglicky

Background Cardiac resynchronization therapy (CRT) is rarely used in patients with congenital heart disease, and reported follow-up is short. We sought to evaluate long-term impact of CRT in a single-center cohort of patients with congenital heart disease. Methods and Results Thirty-two consecutive patients with structural congenital heart disease (N=30) or congenital atrioventricular block (N=2), aged median of 12.9 years at CRT with pacing capability device implantation, were followed up for a median of 8.7 years. CRT response was defined as an increase in systemic ventricular ejection fraction or fractional area of change by &gt;10 units and improved or unchanged New York Heart Association class. Freedom from cardiovascular death, heart failure hospitalization, or new transplant listing was 92.6% and 83.2% at 5 and 10 years, respectively. Freedom from CRT complications, leading to surgical system revision (elective generator replacement excluded) or therapy termination, was 82.7% and 72.2% at 5 and 10 years, respectively. The overall probability of an uneventful therapy continuation was 76.3% and 58.8% at 5 and 10 years, respectively. There was a significant increase in ejection fraction/fractional area of change (P&lt;0.001) mainly attributable to patients with systemic left ventricle (P=0.002) and decrease in systemic ventricular end-diastolic dimensions (P&lt;0.05) after CRT. New York Heart Association functional class improved from a median 2.0 to 1.25 (P&lt;0.001). Long-term CRT response was present in 54.8% of patients at last follow-up and was more frequent in systemic left ventricle (P&lt;0.001). Conclusions CRT in patients with congenital heart disease was associated with acceptable survival and long-term response in approximate to 50% of patients. Probability of an uneventful CRT continuation was modest.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the American Heart Association [online]

ISSN

2047-9980

e-ISSN

—

Svazek periodika

10

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

16

Strana od-do

"art. no. e018302"

Kód UT WoS článku

000630047500031

EID výsledku v databázi Scopus

2-s2.0-85103227865