A plant-based meal affects thalamus perfusion differently than an energy- and macronutrient-matched conventional meal in men with type 2 diabetes, overweight/obese, and healthy men: A three-group randomized crossover study*

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081007" target="_blank" >RIV/00023001:_____/21:00081007 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023761:_____/21:N0000013

Výsledek na webu

<a href="https://www.clinicalnutritionjournal.com/article/S0261-5614(20)30532-X/pdf" target="_blank" >https://www.clinicalnutritionjournal.com/article/S0261-5614(20)30532-X/pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clnu.2020.10.005" target="_blank" >10.1016/j.clnu.2020.10.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A plant-based meal affects thalamus perfusion differently than an energy- and macronutrient-matched conventional meal in men with type 2 diabetes, overweight/obese, and healthy men: A three-group randomized crossover study*

Popis výsledku v původním jazyce

Background &amp; aims: Reward circuitry in the brain plays a key role in weight regulation. We tested the effects of a plant-based meal on these brain regions. Methods: A randomized crossover design was used to test the effects of two energy-and macronutrientmatched meals: a vegan (V-meal) and a conventional meat (M-meal) on brain activity, gastrointestinal hormones, and satiety in participants with type 2 diabetes (T2D; n = 20), overweight/obese participants (O; n = 20), and healthy controls (H; n = 20). Brain perfusion was measured, using arterial spin labeling functional brain imaging; satiety was assessed using a visual analogue scale; and plasma concentrations of gut hormones were determined at 0 and 180 min. Repeated-measures ANOVA was used for statistical analysis. Bonferroni correction for multiple comparisons was applied. The Hedge&apos;s g statistic was used to measure the effect size for means of paired difference between the times (180-0 min) and meal types (M-V meal) for each group. Results: Thalamus perfusion was the highest in patients with T2D and the lowest in overweight/obese individuals (p = 0.001). Thalamus perfusion decreased significantly after ingestion of the M-meal in men with T2D (p = 0.04) and overweight/obese men (p = 0.004), and it decreased significantly after ingestion of the V-meal in healthy controls (p &lt; 0.001; Group x Meal x Time: F = 3.4; p = 0.035). The effect size was-0.41 (95% CI,-1.14 to 0.31; p = 0.26) for men with diabetes;-0.72 (95% CI,-1.48 to 0.01; p = 0.05) for overweight/obese men; and 0.82 (95% CI, 0.09 to 1.59; p = 0.03) for healthy men. Postprandial secretion of active GLP-1 increased after the V-meal compared with the M-meal by 42% (95% CI 25-62%; p = 0.003) in men with T2D and by 41% (95% CI 24-61%; p = 0.002) in healthy controls. Changes in thalamus perfusion after ingestion of both test meals correlated with changes in satiety (r = +0.68; p &lt; 0.01), fasting plasma insulin (r = +0.40; p &lt; 0.01), C-peptide (r = +0.48; p &lt; 0.01) and amylin (r = +0.55; p &lt; 0.01), and insulin secretion at 5 mmol/l (r = +0.77; p &lt; 0.05). Conclusions: The higher postprandial GLP-1 secretion after the V-meal in men with T2D, with concomitant greater satiety and changes in thalamus perfusion, suggest a potential use of plant-based meals in addressing the key pathophysiologic mechanisms of food intake regulation. Trial registration ClinicalTrials.gov number, NCT02474147. 0 2021 Published by Elsevier Ltd.

Název v anglickém jazyce

A plant-based meal affects thalamus perfusion differently than an energy- and macronutrient-matched conventional meal in men with type 2 diabetes, overweight/obese, and healthy men: A three-group randomized crossover study*

Popis výsledku anglicky

Background &amp; aims: Reward circuitry in the brain plays a key role in weight regulation. We tested the effects of a plant-based meal on these brain regions. Methods: A randomized crossover design was used to test the effects of two energy-and macronutrientmatched meals: a vegan (V-meal) and a conventional meat (M-meal) on brain activity, gastrointestinal hormones, and satiety in participants with type 2 diabetes (T2D; n = 20), overweight/obese participants (O; n = 20), and healthy controls (H; n = 20). Brain perfusion was measured, using arterial spin labeling functional brain imaging; satiety was assessed using a visual analogue scale; and plasma concentrations of gut hormones were determined at 0 and 180 min. Repeated-measures ANOVA was used for statistical analysis. Bonferroni correction for multiple comparisons was applied. The Hedge&apos;s g statistic was used to measure the effect size for means of paired difference between the times (180-0 min) and meal types (M-V meal) for each group. Results: Thalamus perfusion was the highest in patients with T2D and the lowest in overweight/obese individuals (p = 0.001). Thalamus perfusion decreased significantly after ingestion of the M-meal in men with T2D (p = 0.04) and overweight/obese men (p = 0.004), and it decreased significantly after ingestion of the V-meal in healthy controls (p &lt; 0.001; Group x Meal x Time: F = 3.4; p = 0.035). The effect size was-0.41 (95% CI,-1.14 to 0.31; p = 0.26) for men with diabetes;-0.72 (95% CI,-1.48 to 0.01; p = 0.05) for overweight/obese men; and 0.82 (95% CI, 0.09 to 1.59; p = 0.03) for healthy men. Postprandial secretion of active GLP-1 increased after the V-meal compared with the M-meal by 42% (95% CI 25-62%; p = 0.003) in men with T2D and by 41% (95% CI 24-61%; p = 0.002) in healthy controls. Changes in thalamus perfusion after ingestion of both test meals correlated with changes in satiety (r = +0.68; p &lt; 0.01), fasting plasma insulin (r = +0.40; p &lt; 0.01), C-peptide (r = +0.48; p &lt; 0.01) and amylin (r = +0.55; p &lt; 0.01), and insulin secretion at 5 mmol/l (r = +0.77; p &lt; 0.05). Conclusions: The higher postprandial GLP-1 secretion after the V-meal in men with T2D, with concomitant greater satiety and changes in thalamus perfusion, suggest a potential use of plant-based meals in addressing the key pathophysiologic mechanisms of food intake regulation. Trial registration ClinicalTrials.gov number, NCT02474147. 0 2021 Published by Elsevier Ltd.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30308 - Nutrition, Dietetics

Projekt

<a href="/cs/project/NV15-27338A" target="_blank" >NV15-27338A: Vliv zpracovávaného masa na oblasti mozku spojené s pocity odměny a závislosti u pacientů s diabetem 2. typu, obézních a zdravých kontrol</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical nutrition

ISSN

0261-5614

e-ISSN

—

Svazek periodika

40

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

1822-1833

Kód UT WoS článku

000640403100042

EID výsledku v databázi Scopus

2-s2.0-85092792414