Apolipoprotein E4 Allele in Subjects with COVID-19

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081043" target="_blank" >RIV/00023001:_____/21:00081043 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/21:10429271 RIV/00216208:11310/21:10429271 RIV/00216224:14110/21:00121856

Výsledek na webu

<a href="https://www.karger.com/Article/Pdf/516200" target="_blank" >https://www.karger.com/Article/Pdf/516200</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1159/000516200" target="_blank" >10.1159/000516200</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Apolipoprotein E4 Allele in Subjects with COVID-19

Popis výsledku v původním jazyce

We analysed the APOE4 polymorphism (rs429358) in a group of 408 Czech first-wave (approximately March 2020–June 2020) SARS-CoV-2 PCR-positive (PCR test) subjects (54.7% females, mean age 44 ± 15 years, diabetes prevalence 7.8%, hypertension prevalence 13.3%). Of this total number, 164 were asymptomatic and 244 symptomatic. . We found no significant differences between the entire group of SARS-CoV-2-positive subjects and the control population (χ 2 test; p = 0.11). However, after applying disease status (asymptomatic and symptomatic subjects were separately compared with the control population) to our model, the frequency of carriers of at least one APOE4 allele was significantly higher in symptomatic COVID-19 subjects than in controls (p = 0.03; OR, 95% CI – 1.43, 1.05–1.95). In contrast, genotype frequencies were almost identical in COVID-19-asymptomatic (SARS-CoV2-positive) subjects and in the control group population (p = 0.86).

Název v anglickém jazyce

Apolipoprotein E4 Allele in Subjects with COVID-19

Popis výsledku anglicky

We analysed the APOE4 polymorphism (rs429358) in a group of 408 Czech first-wave (approximately March 2020–June 2020) SARS-CoV-2 PCR-positive (PCR test) subjects (54.7% females, mean age 44 ± 15 years, diabetes prevalence 7.8%, hypertension prevalence 13.3%). Of this total number, 164 were asymptomatic and 244 symptomatic. . We found no significant differences between the entire group of SARS-CoV-2-positive subjects and the control population (χ 2 test; p = 0.11). However, after applying disease status (asymptomatic and symptomatic subjects were separately compared with the control population) to our model, the frequency of carriers of at least one APOE4 allele was significantly higher in symptomatic COVID-19 subjects than in controls (p = 0.03; OR, 95% CI – 1.43, 1.05–1.95). In contrast, genotype frequencies were almost identical in COVID-19-asymptomatic (SARS-CoV2-positive) subjects and in the control group population (p = 0.86).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30303 - Infectious Diseases

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Gerontology

ISSN

0304-324X

e-ISSN

—

Svazek periodika

67

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

3

Strana od-do

320-322

Kód UT WoS článku

000659535900009

EID výsledku v databázi Scopus

2-s2.0-85107714553