Giant cell myocarditis in young woman diagnosed at the autopsy: a case report

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081533" target="_blank" >RIV/00023001:_____/21:00081533 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/21:43922037 RIV/00064173:_____/21:N0000095

Výsledek na webu

<a href="https://www.prolekare.cz/casopisy/cesko-slovenska-patologie/2021-3-14/obrovskobunecna-myokarditida-u-mlade-zeny-odhalena-pri-pitve-kazuistika-128091/download?hl=cs" target="_blank" >https://www.prolekare.cz/casopisy/cesko-slovenska-patologie/2021-3-14/obrovskobunecna-myokarditida-u-mlade-zeny-odhalena-pri-pitve-kazuistika-128091/download?hl=cs</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Giant cell myocarditis in young woman diagnosed at the autopsy: a case report

Popis výsledku v původním jazyce

Giant cell myocarditis (GCM) is a rare inflammatory disease of the heart that often affects younger patients. The clinical course is typically rapid with fulminant congestive heart failure. Prognosis is poor; the proper diagnosis is often rendered at the autopsy.Herein, we present a prototypical case of this rare type of myocarditis, affecting a 44-year-old previously healthy woman who was referred to the intensive care department due to an acute onset cardiac arrest followed by resuscitation. The heart ultrasound and imaging examinations revealed a severe dysfunction and dilatation of both ventricles, without any significant finding in the coronary arteries. Twelve days after the initial presentation, the patient died due to congestive heart failure refractory to intensive therapy. The post-mortem histology of the heart revealed multiple small necrotic foci in the myocardium in both ventricles, with dense inflammatory infiltration with abundant multinucleated giant histiocytes, in line with a diagnosis of GCM.The natural history, pathophysiology, and histological differential diagnosis is discussed, together with review of the relevant literature including uncommon and emerging units.

Název v anglickém jazyce

Giant cell myocarditis in young woman diagnosed at the autopsy: a case report

Popis výsledku anglicky

Giant cell myocarditis (GCM) is a rare inflammatory disease of the heart that often affects younger patients. The clinical course is typically rapid with fulminant congestive heart failure. Prognosis is poor; the proper diagnosis is often rendered at the autopsy.Herein, we present a prototypical case of this rare type of myocarditis, affecting a 44-year-old previously healthy woman who was referred to the intensive care department due to an acute onset cardiac arrest followed by resuscitation. The heart ultrasound and imaging examinations revealed a severe dysfunction and dilatation of both ventricles, without any significant finding in the coronary arteries. Twelve days after the initial presentation, the patient died due to congestive heart failure refractory to intensive therapy. The post-mortem histology of the heart revealed multiple small necrotic foci in the myocardium in both ventricles, with dense inflammatory infiltration with abundant multinucleated giant histiocytes, in line with a diagnosis of GCM.The natural history, pathophysiology, and histological differential diagnosis is discussed, together with review of the relevant literature including uncommon and emerging units.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

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OECD FORD obor

30109 - Pathology

Projekt

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Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česko-slovenská patologie a soudní lékařství

ISSN

1210-7875

e-ISSN

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Svazek periodika

57

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

174-178

Kód UT WoS článku

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EID výsledku v databázi Scopus

2-s2.0-85116781676