Gut microbiota as the link between elevated BCAA serum levels and insulin resistance

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F21%3A00081874" target="_blank" >RIV/00023001:_____/21:00081874 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/21:43922254 RIV/00064173:_____/21:N0000195

Výsledek na webu

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533624/pdf/biomolecules-11-01414.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8533624/pdf/biomolecules-11-01414.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/biom11101414" target="_blank" >10.3390/biom11101414</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Gut microbiota as the link between elevated BCAA serum levels and insulin resistance

Popis výsledku v původním jazyce

The microbiota-harboring human gut is an exquisitely active ecosystem that has evolved in a constant symbiosis with the human host. It produces numerous compounds depending on its metabolic capacity and substrates availability. Diet is the major source of the substrates that are metabolized to end-products, further serving as signal molecules in the microbiota-host cross-talk. Among these signal molecules, branched-chain amino acids (BCAAs) has gained significant scien-tific attention. BCAAs are abundant in animal-based dietary sources; they are both produced and degraded by gut microbiota and the host circulating levels are associated with the risk of type 2 diabetes. This review aims to summarize the current knowledge on the complex relationship between gut microbiota and its functional capacity to handle BCAAs as well as the host BCAA metabolism in insulin resistance development. Targeting gut microbiota BCAA metabolism with a dietary modulation could represent a promising approach in the prevention and treatment of insulin resistance related states, such as obesity and diabetes. © 2021 by the authors. Li-censee MDPI, Basel, Switzerland.

Název v anglickém jazyce

Gut microbiota as the link between elevated BCAA serum levels and insulin resistance

Popis výsledku anglicky

The microbiota-harboring human gut is an exquisitely active ecosystem that has evolved in a constant symbiosis with the human host. It produces numerous compounds depending on its metabolic capacity and substrates availability. Diet is the major source of the substrates that are metabolized to end-products, further serving as signal molecules in the microbiota-host cross-talk. Among these signal molecules, branched-chain amino acids (BCAAs) has gained significant scien-tific attention. BCAAs are abundant in animal-based dietary sources; they are both produced and degraded by gut microbiota and the host circulating levels are associated with the risk of type 2 diabetes. This review aims to summarize the current knowledge on the complex relationship between gut microbiota and its functional capacity to handle BCAAs as well as the host BCAA metabolism in insulin resistance development. Targeting gut microbiota BCAA metabolism with a dietary modulation could represent a promising approach in the prevention and treatment of insulin resistance related states, such as obesity and diabetes. © 2021 by the authors. Li-censee MDPI, Basel, Switzerland.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

<a href="/cs/project/NV18-01-00040" target="_blank" >NV18-01-00040: Modifikace střevní mikrobioty v léčbě inzulínové rezistence: personalizovaný přístup</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomolecules

ISSN

2218-273X

e-ISSN

—

Svazek periodika

11

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

16

Strana od-do

"art. no. 1414"

Kód UT WoS článku

000726383400001

EID výsledku v databázi Scopus

2-s2.0-85115840196