Adiponectin, A-FABP and FGF-19 Levels in Women with Early Diagnosed Gestational Diabetes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00082618" target="_blank" >RIV/00023001:_____/22:00082618 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/22:10157278 RIV/61989592:15110/22:73614241

Výsledek na webu

<a href="https://www.mdpi.com/2077-0383/11/9/2417" target="_blank" >https://www.mdpi.com/2077-0383/11/9/2417</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/jcm11092417" target="_blank" >10.3390/jcm11092417</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Adiponectin, A-FABP and FGF-19 Levels in Women with Early Diagnosed Gestational Diabetes

Popis výsledku v původním jazyce

Background: Adiponectin, adipocyte fatty acid-binding protein (A-FABP), and fibroblast growth factor-19 (FGF-19) belong to proteins involved in glucose metabolism regulation. The aims of the study were to compare the plasma levels of these proteins in women with early diagnosed gestational diabetes mellitus (GDM) to those in healthy controls and to investigate their changes during pregnancy after early intervention. Methods: The study was undertaken as a case-control study. Early GDM diagnosis was based on repeated fasting plasma glucose ≥5.1 and &lt;7.0 mmol/L during the first trimester of pregnancy and exclusion of overt diabetes. Age-matched controls com-prised healthy pregnant and non-pregnant women. In addition to adipokines, clinical parameters and measures of glucose control were assessed. Results: Women with GDM (n = 23) had significantly lower adiponectin and higher A-FABP levels compared to healthy pregnant (n = 29) or non-pregnant (n = 25) controls, while no significant differences in FGF-19 between the groups were found. The therapeutic intervention shifted adiponectin and A-FABP levels in GDM women towards concentrations of healthy pregnant controls. Adipokines were associated with visceral adiposity and glucose control. Conclusion: Women with GDM showed altered adipokine production even in the first trimester of pregnancy. Early therapeutic intervention not only improved glucose control but also normalized impaired adipokine production. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Název v anglickém jazyce

Adiponectin, A-FABP and FGF-19 Levels in Women with Early Diagnosed Gestational Diabetes

Popis výsledku anglicky

Background: Adiponectin, adipocyte fatty acid-binding protein (A-FABP), and fibroblast growth factor-19 (FGF-19) belong to proteins involved in glucose metabolism regulation. The aims of the study were to compare the plasma levels of these proteins in women with early diagnosed gestational diabetes mellitus (GDM) to those in healthy controls and to investigate their changes during pregnancy after early intervention. Methods: The study was undertaken as a case-control study. Early GDM diagnosis was based on repeated fasting plasma glucose ≥5.1 and &lt;7.0 mmol/L during the first trimester of pregnancy and exclusion of overt diabetes. Age-matched controls com-prised healthy pregnant and non-pregnant women. In addition to adipokines, clinical parameters and measures of glucose control were assessed. Results: Women with GDM (n = 23) had significantly lower adiponectin and higher A-FABP levels compared to healthy pregnant (n = 29) or non-pregnant (n = 25) controls, while no significant differences in FGF-19 between the groups were found. The therapeutic intervention shifted adiponectin and A-FABP levels in GDM women towards concentrations of healthy pregnant controls. Adipokines were associated with visceral adiposity and glucose control. Conclusion: Women with GDM showed altered adipokine production even in the first trimester of pregnancy. Early therapeutic intervention not only improved glucose control but also normalized impaired adipokine production. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

<a href="/cs/project/NV18-01-00139" target="_blank" >NV18-01-00139: Gestační diabetes mellitus - podíl hormonů entero-insulární osy, vybraných adipokinů a střevní mikroflóry na vznik jeho různých fenotypů</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of clinical medicine

ISSN

2077-0383

e-ISSN

2077-0383

Svazek periodika

11

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

11

Strana od-do

"art. no. 2417"

Kód UT WoS článku

000799316200001

EID výsledku v databázi Scopus

2-s2.0-85128782196