Surgery and outcome of infective endocarditis in octogenarians: prospective data from the ESC EORP EURO-ENDO registry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00083459" target="_blank" >RIV/00023001:_____/22:00083459 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/22:10441995

Výsledek na webu

<a href="https://link.springer.com/content/pdf/10.1007/s15010-022-01792-0.pdf?pdf=button" target="_blank" >https://link.springer.com/content/pdf/10.1007/s15010-022-01792-0.pdf?pdf=button</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s15010-022-01792-0" target="_blank" >10.1007/s15010-022-01792-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Surgery and outcome of infective endocarditis in octogenarians: prospective data from the ESC EORP EURO-ENDO registry

Popis výsledku v původním jazyce

Purpose High mortality and a limited performance of valvular surgery are typical features of infective endocarditis (IE) in octogenarians, even though surgical treatment is a major determinant of a successful outcome in IE. Methods Data from the prospective multicentre ESC EORP EURO-ENDO registry were used to assess the prognostic role of valvular surgery depending on age. Results As compared to &lt; 80 yo patients, &gt;= 80 yo had lower rates of theoretical indication for valvular surgery (49.1% vs. 60.3%, p &lt; 0.001), of surgery performed (37.0% vs. 75.5%, p &lt; 0.001), and a higher in-hospital (25.9% vs. 15.8%, p &lt; 0.001) and 1-year mortality (41.3% vs. 22.2%, p &lt; 0.001). By multivariable analysis, age per se was not predictive of 1-year mortality, but lack of surgical procedures when indicated was strongly predictive (HR 2.98 [2.43-3.66]). By propensity analysis, 304 &gt;= 80 yo were matched to 608 &lt; 80 yo patients. Propensity analysis confirmed the lower rate of indication for valvular surgery (51.3% vs. 57.2%, p = 0.031) and of surgery performed (35.3% vs. 68.4%, p &lt; 0.0001) in &gt;= 80 yo. Overall mortality remained higher in &gt;= 80 yo (in-hospital: HR 1.50[1.06-2.13], p = 0.0210; 1-yr: HR 1.58[1.21-2.05], p = 0.0006), but was not different from that of &lt; 80 yo among those who had surgery (in-hospital: 19.7% vs. 20.0%, p = 0.4236; 1-year: 27.3% vs. 25.5%, p = 0.7176). Conclusion Although mortality rates are consistently higher in &gt;= 80 yo patients than in &lt; 80 yo patients in the general population, mortality of surgery in &gt;= 80 yo is similar to &lt; 80 yo after matching patients. These results confirm the importance of a better recognition of surgical indication and of an increased performance of surgery in &gt;= 80 yo patients.

Název v anglickém jazyce

Surgery and outcome of infective endocarditis in octogenarians: prospective data from the ESC EORP EURO-ENDO registry

Popis výsledku anglicky

Purpose High mortality and a limited performance of valvular surgery are typical features of infective endocarditis (IE) in octogenarians, even though surgical treatment is a major determinant of a successful outcome in IE. Methods Data from the prospective multicentre ESC EORP EURO-ENDO registry were used to assess the prognostic role of valvular surgery depending on age. Results As compared to &lt; 80 yo patients, &gt;= 80 yo had lower rates of theoretical indication for valvular surgery (49.1% vs. 60.3%, p &lt; 0.001), of surgery performed (37.0% vs. 75.5%, p &lt; 0.001), and a higher in-hospital (25.9% vs. 15.8%, p &lt; 0.001) and 1-year mortality (41.3% vs. 22.2%, p &lt; 0.001). By multivariable analysis, age per se was not predictive of 1-year mortality, but lack of surgical procedures when indicated was strongly predictive (HR 2.98 [2.43-3.66]). By propensity analysis, 304 &gt;= 80 yo were matched to 608 &lt; 80 yo patients. Propensity analysis confirmed the lower rate of indication for valvular surgery (51.3% vs. 57.2%, p = 0.031) and of surgery performed (35.3% vs. 68.4%, p &lt; 0.0001) in &gt;= 80 yo. Overall mortality remained higher in &gt;= 80 yo (in-hospital: HR 1.50[1.06-2.13], p = 0.0210; 1-yr: HR 1.58[1.21-2.05], p = 0.0006), but was not different from that of &lt; 80 yo among those who had surgery (in-hospital: 19.7% vs. 20.0%, p = 0.4236; 1-year: 27.3% vs. 25.5%, p = 0.7176). Conclusion Although mortality rates are consistently higher in &gt;= 80 yo patients than in &lt; 80 yo patients in the general population, mortality of surgery in &gt;= 80 yo is similar to &lt; 80 yo after matching patients. These results confirm the importance of a better recognition of surgical indication and of an increased performance of surgery in &gt;= 80 yo patients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Infection

ISSN

0300-8126

e-ISSN

1439-0973

Svazek periodika

50

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

12

Strana od-do

1191-1202

Kód UT WoS článku

000769270400001

EID výsledku v databázi Scopus

2-s2.0-85127808545