Association between gestational diabetes mellitus and bioavailability of insulin-like growth factors and role of their binding proteins

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00083557" target="_blank" >RIV/00023001:_____/22:00083557 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/22:10453005 RIV/00064165:_____/22:10453005

Výsledek na webu

<a href="https://reader.elsevier.com/reader/sd/pii/S1096637422000685?token=4301BF2AA3471A342851273D5E9AEBA989791A462E1DE190A29B59DB2A67D493B3EBAFE4D7A003682E9B28A9FAAC5E1E&originRegion=eu-west-1&originCreation=20230206123107" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S1096637422000685?token=4301BF2AA3471A342851273D5E9AEBA989791A462E1DE190A29B59DB2A67D493B3EBAFE4D7A003682E9B28A9FAAC5E1E&originRegion=eu-west-1&originCreation=20230206123107</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ghir.2022.101511" target="_blank" >10.1016/j.ghir.2022.101511</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Association between gestational diabetes mellitus and bioavailability of insulin-like growth factors and role of their binding proteins

Popis výsledku v původním jazyce

Objective: Insulin-like growth factors (IGFs) are involved in regulating growth and metabolism and increase in-sulin sensitivity, improve glucose metabolism, and are potentially related to gestational diabetes mellitus (GDM) and its complications for mothers and fetuses.Design: This study aimed to assess serum levels and cord blood levels of IGF system components in pregnant women with (39 participants) and without GDM (22 participants). Blood samples were obtained at 28-32 and 36-38 weeks of gestation and 6-12 months after delivery. Cord blood samples were obtained during delivery. Results between both groups as well as between single visits were statistically compared.Results: Both IGF1 and IGF2 maternal serum levels did not differ between the GDM and non-GDM groups. However, levels of IGF-binding proteins (IGFBPs) were different. IGFBP4 levels were decreased during pregnancy and after delivery in women with GDM, while IGFBP7 levels were increased during pregnancy in women with GDM. Cord blood IGFBP3 and IGFBP7 levels were increased (p &lt; 0.001 for IGFBP3, p = 0.003 for IGFBP7), while IGFBP4 levels were decreased (p &lt; 0.001) in the GDM group compared with the non-GDM group. Conclusions: Although IGF levels did not differ, changes in their function level could still persist possibly because of the effects of the binding proteins, especially their promoting or inhibitory effects on IGFs. These results should be considered in interpretation of IGF levels.

Název v anglickém jazyce

Association between gestational diabetes mellitus and bioavailability of insulin-like growth factors and role of their binding proteins

Popis výsledku anglicky

Objective: Insulin-like growth factors (IGFs) are involved in regulating growth and metabolism and increase in-sulin sensitivity, improve glucose metabolism, and are potentially related to gestational diabetes mellitus (GDM) and its complications for mothers and fetuses.Design: This study aimed to assess serum levels and cord blood levels of IGF system components in pregnant women with (39 participants) and without GDM (22 participants). Blood samples were obtained at 28-32 and 36-38 weeks of gestation and 6-12 months after delivery. Cord blood samples were obtained during delivery. Results between both groups as well as between single visits were statistically compared.Results: Both IGF1 and IGF2 maternal serum levels did not differ between the GDM and non-GDM groups. However, levels of IGF-binding proteins (IGFBPs) were different. IGFBP4 levels were decreased during pregnancy and after delivery in women with GDM, while IGFBP7 levels were increased during pregnancy in women with GDM. Cord blood IGFBP3 and IGFBP7 levels were increased (p &lt; 0.001 for IGFBP3, p = 0.003 for IGFBP7), while IGFBP4 levels were decreased (p &lt; 0.001) in the GDM group compared with the non-GDM group. Conclusions: Although IGF levels did not differ, changes in their function level could still persist possibly because of the effects of the binding proteins, especially their promoting or inhibitory effects on IGFs. These results should be considered in interpretation of IGF levels.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

<a href="/cs/project/NU20-01-00067" target="_blank" >NU20-01-00067: Vliv kompenzace diabetu na placentární funkce a fetální cirkulaci u těhotných žen s diabetem 1. typu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Growth hormone &amp; IGF research

ISSN

1096-6374

e-ISSN

1532-2238

Svazek periodika

67

Číslo periodika v rámci svazku

December

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

"art. no. 101511"

Kód UT WoS článku

000904437500002

EID výsledku v databázi Scopus

2-s2.0-85140918913