Class II HLA in Georgia Caucasus Tbilisi Georgians and their Mediterranean ancestry : the Usko Mediterranean languages
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F22%3A00083662" target="_blank" >RIV/00023001:_____/22:00083662 - isvavai.cz</a>
Výsledek na webu
<a href="https://reader.elsevier.com/reader/sd/pii/S0198885922001598?token=84CF230B7B0B9B40FF9487390AEFCE7EFE04612BD290D3188DB80B1DA8202D4F2399ADB3BE117123FB11347A1347D8BD&originRegion=eu-west-1&originCreation=20230306084313" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S0198885922001598?token=84CF230B7B0B9B40FF9487390AEFCE7EFE04612BD290D3188DB80B1DA8202D4F2399ADB3BE117123FB11347A1347D8BD&originRegion=eu-west-1&originCreation=20230306084313</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.humimm.2022.08.005" target="_blank" >10.1016/j.humimm.2022.08.005</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Class II HLA in Georgia Caucasus Tbilisi Georgians and their Mediterranean ancestry : the Usko Mediterranean languages
Popis výsledku v původním jazyce
Georgia (or Sakartvelo in its own language) is a South Caucasus Mts. country with its easternmost part is enig-matically named Iberia, like the Iberian Peninsula, which may refer to rivers "Kura" and "Ebro" or their valleys respectively. Most of their inhabitants speak Georgian which is included within Dene-Caucasian group and Usko-Mediterranean subgroup of languages. The latter includes Basque, Berber, ancient Iberian-Tartessian, Etruscan, Hittite, Minoan Lineal A and others. In the present paper, HLA class II-DRB1 and-DQB1 alleles has been studied and extended haplotypes calculated. Most frequent haplotypes are also of Mediterranean ori-gin (i. e.: (A*02-B*51)-DRB1*11:01-DQB1*03:01, (A*02-B*51)-DRB1*13:01-DQB1*06:03, or (A*24-B*35)-D RB1*01:01-DQB1*05:01) and DA genetic distances show that closest world populations to Georgians are Mediterraneans. Georgians also show common extended haplotypes ((A*02-B*51)-DRB1*11:01-DQB1*03:01 , (A*02-B*13)-DRB1*07:01-DQB1*02:01 and (A*03-B*35)-DRB1*11:01-DQB1*03:01) with Svan people, a secluded population in North Georgia mountains. We can conclude that Georgians belong to a very old Mediterranean substratum according to both linguistics (Usko Mediterranean languages) and HLA genetics.
Název v anglickém jazyce
Class II HLA in Georgia Caucasus Tbilisi Georgians and their Mediterranean ancestry : the Usko Mediterranean languages
Popis výsledku anglicky
Georgia (or Sakartvelo in its own language) is a South Caucasus Mts. country with its easternmost part is enig-matically named Iberia, like the Iberian Peninsula, which may refer to rivers "Kura" and "Ebro" or their valleys respectively. Most of their inhabitants speak Georgian which is included within Dene-Caucasian group and Usko-Mediterranean subgroup of languages. The latter includes Basque, Berber, ancient Iberian-Tartessian, Etruscan, Hittite, Minoan Lineal A and others. In the present paper, HLA class II-DRB1 and-DQB1 alleles has been studied and extended haplotypes calculated. Most frequent haplotypes are also of Mediterranean ori-gin (i. e.: (A*02-B*51)-DRB1*11:01-DQB1*03:01, (A*02-B*51)-DRB1*13:01-DQB1*06:03, or (A*24-B*35)-D RB1*01:01-DQB1*05:01) and DA genetic distances show that closest world populations to Georgians are Mediterraneans. Georgians also show common extended haplotypes ((A*02-B*51)-DRB1*11:01-DQB1*03:01 , (A*02-B*13)-DRB1*07:01-DQB1*02:01 and (A*03-B*35)-DRB1*11:01-DQB1*03:01) with Svan people, a secluded population in North Georgia mountains. We can conclude that Georgians belong to a very old Mediterranean substratum according to both linguistics (Usko Mediterranean languages) and HLA genetics.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30102 - Immunology
Návaznosti výsledku
Projekt
—
Návaznosti
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Ostatní
Rok uplatnění
2022
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Human immunology
ISSN
0198-8859
e-ISSN
1879-1166
Svazek periodika
83
Číslo periodika v rámci svazku
11
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
2
Strana od-do
739-740
Kód UT WoS článku
000918357300002
EID výsledku v databázi Scopus
2-s2.0-85136102416