Fibronectin in hyperglycaemia and its potential use in the treatment of diabetic foot ulcers: a review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00083815" target="_blank" >RIV/00023001:_____/23:00083815 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/23:10451967 RIV/00216208:11120/23:43924465 RIV/00216208:11140/23:10451967 RIV/00216208:11150/23:10451967

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.13997" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.13997</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/iwj.13997" target="_blank" >10.1111/iwj.13997</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Fibronectin in hyperglycaemia and its potential use in the treatment of diabetic foot ulcers: a review

Popis výsledku v původním jazyce

Metabolism of fibronectin, the protein that plays a key role in the healing of wounds, is changed in the patients with diabetes mellitus. Fibronectin can interact with other proteins and proteoglycans and organise them to form the extracellular matrix, the basis of the granulation tissue in healing wounds. However, diabetic foot ulcers (DFUs) suffer from inadequate deposition of this protein. Degradation prevails over fibronectin synthesis in the proteolytic inflammatory environment in the ulcers. Because of the lack of fibronectin in the wound bed, the assembly of the extracellular matrix and the deposition of the granulation tissue cannot be started. A number of methods have been designed that prevents fibronectin degradation, replace lacking fibronectin or support its formation in non-healing wounds in animal models of diabetes. The aim of this article is to review the metabolism of fibronectin in DFUs and to emphasise that it would be useful to pay more attention to fibronectin matrix assembly in the ulcers when laboratory methods are translated to clinical practice.

Název v anglickém jazyce

Fibronectin in hyperglycaemia and its potential use in the treatment of diabetic foot ulcers: a review

Popis výsledku anglicky

Metabolism of fibronectin, the protein that plays a key role in the healing of wounds, is changed in the patients with diabetes mellitus. Fibronectin can interact with other proteins and proteoglycans and organise them to form the extracellular matrix, the basis of the granulation tissue in healing wounds. However, diabetic foot ulcers (DFUs) suffer from inadequate deposition of this protein. Degradation prevails over fibronectin synthesis in the proteolytic inflammatory environment in the ulcers. Because of the lack of fibronectin in the wound bed, the assembly of the extracellular matrix and the deposition of the granulation tissue cannot be started. A number of methods have been designed that prevents fibronectin degradation, replace lacking fibronectin or support its formation in non-healing wounds in animal models of diabetes. The aim of this article is to review the metabolism of fibronectin in DFUs and to emphasise that it would be useful to pay more attention to fibronectin matrix assembly in the ulcers when laboratory methods are translated to clinical practice.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International wound journal

ISSN

1742-4801

e-ISSN

1742-481X

Svazek periodika

20

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

1750-1761

Kód UT WoS článku

000900010200001

EID výsledku v databázi Scopus

2-s2.0-85144258127