Predictors of significant liver fibrosis in people with chronic hepatitis C who inject drugs in the Czech Republic

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00083864" target="_blank" >RIV/00023001:_____/23:00083864 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/23:43925388 RIV/00064173:_____/23:43925388

Výsledek na webu

<a href="https://www.mdpi.com/2075-1729/13/4/932" target="_blank" >https://www.mdpi.com/2075-1729/13/4/932</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/life13040932" target="_blank" >10.3390/life13040932</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Predictors of significant liver fibrosis in people with chronic hepatitis C who inject drugs in the Czech Republic

Popis výsledku v původním jazyce

Background and objectives: HCV infection often remains untreated in people who inject drugs (PWID), albeit they may present with advanced liver fibrosis at a young age. We aimed to assess the rate of patients with significant fibrosis in PWID starting anti-HCV therapy and identify the factors associated with severe fibrosis. Methods: The cohort of 200 patients was divided into two groups: F0-F2 (N = 154, 77%), patients with liver stiffness measurement (LSM) &lt; 10.0 kPa, and F3-F4 (N = 46, 23%), with LSM &gt;= 10.0 kPa, indicating significant liver fibrosis. Results: In group F3-F4, there were significantly more males, and the patients were older, with a higher BMI. The number of long-term abstaining patients was significantly higher in group F3-F4 compared with group F0-F2, as well as the proportion of patients reporting harmful drinking. Obesity (OR 4.77), long-term abstinence from illicit drugs (OR 4.06), harmful drinking (OR 2.83), and older age (OR 1.17) were significant predictors of advanced fibrosis in PWID starting anti-HCV therapy. Conclusions: A quarter of PWID presented with significant liver fibrosis at treatment initiation. Obesity, long-term drug abstinence, harmful drinking, and older age contributed to significant liver fibrosis.

Název v anglickém jazyce

Predictors of significant liver fibrosis in people with chronic hepatitis C who inject drugs in the Czech Republic

Popis výsledku anglicky

Background and objectives: HCV infection often remains untreated in people who inject drugs (PWID), albeit they may present with advanced liver fibrosis at a young age. We aimed to assess the rate of patients with significant fibrosis in PWID starting anti-HCV therapy and identify the factors associated with severe fibrosis. Methods: The cohort of 200 patients was divided into two groups: F0-F2 (N = 154, 77%), patients with liver stiffness measurement (LSM) &lt; 10.0 kPa, and F3-F4 (N = 46, 23%), with LSM &gt;= 10.0 kPa, indicating significant liver fibrosis. Results: In group F3-F4, there were significantly more males, and the patients were older, with a higher BMI. The number of long-term abstaining patients was significantly higher in group F3-F4 compared with group F0-F2, as well as the proportion of patients reporting harmful drinking. Obesity (OR 4.77), long-term abstinence from illicit drugs (OR 4.06), harmful drinking (OR 2.83), and older age (OR 1.17) were significant predictors of advanced fibrosis in PWID starting anti-HCV therapy. Conclusions: A quarter of PWID presented with significant liver fibrosis at treatment initiation. Obesity, long-term drug abstinence, harmful drinking, and older age contributed to significant liver fibrosis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Life

ISSN

2075-1729

e-ISSN

2075-1729

Svazek periodika

13

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

12

Strana od-do

"art. no. 932"

Kód UT WoS článku

000977581800001

EID výsledku v databázi Scopus

2-s2.0-85154058280