Attenuation of hypocretin/orexin signaling is associated with increased mortality after myocardial infarction

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00083895" target="_blank" >RIV/00023001:_____/23:00083895 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/23:10458572 RIV/00216208:11120/23:43925324

Výsledek na webu

<a href="https://www.ahajournals.org/doi/epdf/10.1161/JAHA.122.028987" target="_blank" >https://www.ahajournals.org/doi/epdf/10.1161/JAHA.122.028987</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1161/JAHA.122.028987" target="_blank" >10.1161/JAHA.122.028987</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Attenuation of hypocretin/orexin signaling is associated with increased mortality after myocardial infarction

Popis výsledku v původním jazyce

BACKGROUND: The hypocretin/orexin system has been shown to play a role in heart failure. Whether it also influences myocar-dial infarction (MI) outcomes is unknown. We evaluated the effect of the rs7767652 minor allele T associated with decreased transcription of the hypocretin/orexin receptor-2 and circulating orexin A concentrations on mortality risk after MI. METHODS AND RESULTS: Data from a single-center, prospectively designed registry of consecutive patients hospitalized for MI at a large tertiary cardiology center were analyzed. Patients without previous history of MI or heart failure were included. A random population sample was used to compare allele frequencies in the general population. Out of 1009 patients (aged 64±12 years, 74.6% men) after MI, 6.1% were homozygotes (TT) and 39.4% heterozygotes (CT) for minor allele. Allele frequencies in the MI group did not differ from 1953 subjects from general population (χ2 P=0.62). At index hospitalization, MI size was the same, but ventricular fibrillation and the need for cardiopulmonary resuscitation were more prevalent in the TT allele variant. Among patients with ejection fraction ≤40% at discharge, the TT variant was associated with a lower increase in left ventricular ejection fraction during follow-up (P=0.03). During the 27-month follow-up, there was a statistically significant association of the TT variant with increased mortality risk (hazard ratio [HR], 2.83; P=0.001). Higher circulating orexin A was associated with a lower mortality risk (HR, 0.41; P&lt;0.05). CONCLUSIONS: Attenuation of hypocretin/orexin signaling is associated with increased mortality risk after MI. This effect may be partially explained by the increased arrhythmic risk and the effect on the left ventricular systolic function recovery. © 2023 The Authors. Published on behalf of the American Heart Association, Inc.,.

Název v anglickém jazyce

Attenuation of hypocretin/orexin signaling is associated with increased mortality after myocardial infarction

Popis výsledku anglicky

BACKGROUND: The hypocretin/orexin system has been shown to play a role in heart failure. Whether it also influences myocar-dial infarction (MI) outcomes is unknown. We evaluated the effect of the rs7767652 minor allele T associated with decreased transcription of the hypocretin/orexin receptor-2 and circulating orexin A concentrations on mortality risk after MI. METHODS AND RESULTS: Data from a single-center, prospectively designed registry of consecutive patients hospitalized for MI at a large tertiary cardiology center were analyzed. Patients without previous history of MI or heart failure were included. A random population sample was used to compare allele frequencies in the general population. Out of 1009 patients (aged 64±12 years, 74.6% men) after MI, 6.1% were homozygotes (TT) and 39.4% heterozygotes (CT) for minor allele. Allele frequencies in the MI group did not differ from 1953 subjects from general population (χ2 P=0.62). At index hospitalization, MI size was the same, but ventricular fibrillation and the need for cardiopulmonary resuscitation were more prevalent in the TT allele variant. Among patients with ejection fraction ≤40% at discharge, the TT variant was associated with a lower increase in left ventricular ejection fraction during follow-up (P=0.03). During the 27-month follow-up, there was a statistically significant association of the TT variant with increased mortality risk (hazard ratio [HR], 2.83; P=0.001). Higher circulating orexin A was associated with a lower mortality risk (HR, 0.41; P&lt;0.05). CONCLUSIONS: Attenuation of hypocretin/orexin signaling is associated with increased mortality risk after MI. This effect may be partially explained by the increased arrhythmic risk and the effect on the left ventricular systolic function recovery. © 2023 The Authors. Published on behalf of the American Heart Association, Inc.,.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the American Heart Association [online]

ISSN

2047-9980

e-ISSN

2047-9980

Svazek periodika

12

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

"art. no. e028987"

Kód UT WoS článku

000956680700043

EID výsledku v databázi Scopus

2-s2.0-85150751029