Right ventricular global dysfunction score : a new concept of right ventricular function assessment in patients with heart failure with reduced ejection fraction (HFrEF)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084105" target="_blank" >RIV/00023001:_____/23:00084105 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.frontiersin.org/articles/10.3389/fcvm.2023.1194174/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fcvm.2023.1194174/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fcvm.2023.1194174" target="_blank" >10.3389/fcvm.2023.1194174</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Right ventricular global dysfunction score : a new concept of right ventricular function assessment in patients with heart failure with reduced ejection fraction (HFrEF)

Popis výsledku v původním jazyce

BackgroundRight ventricular (RV) function is currently being evaluated solely according to the properties of RV myocardium. We have tested a concept that in patients with heart failure with reduced ejection fraction (HFrEF), RV assessment should integrate the information about both RV function as well as size. MethodsA total of 836 stable patients with HFrEF (LVEF 23.6 &amp; PLUSMN; 5.8%, 82.8% males, 68% NYHA III/IV) underwent echocardiographic evaluation and were prospectively followed for a median of 3.07 (IQRs 1.11; 4.89) years for the occurrence of death, urgent heart transplantation or implantation of mechanical circulatory support. ResultsRV size (measured as RV-basal diameter, RVD1) was significantly associated with an adverse outcome independent of RV dysfunction grade (p = 0.0002). The prognostic power of RVD1 was further improved by indexing to body surface area (RVD(1)i, p &lt; 0.05 compared to non-indexed value). A novel parameter named RV global dysfunction score (RVGDs) was calculated as a product of RVD(1)i and the degree of RV dysfunction (1-4 for preserved RV function, mild, moderate and severe dysfunction, respectively). RVGDs showed a superior prognostic role compared to RV dysfunction grade alone (&amp; UDelta;AUC &gt;0.03, p &lt; 0.0001). In every subgroup of RVGDs (&lt;20, 20-40, 40-60, &gt;60), patients with milder degree of RV dysfunction but more dilated RV had similar outcome as those with more severe degree of RV dysfunction but smaller RV size (all p &gt; 0.50), independent of tricuspid regurgitation severity and degree of pulmonary hypertension. ConclusionRV dilatation is a manifestation of RV dysfunction. The evaluation of RV performance should integrate the information about both RV size and function.

Název v anglickém jazyce

Right ventricular global dysfunction score : a new concept of right ventricular function assessment in patients with heart failure with reduced ejection fraction (HFrEF)

Popis výsledku anglicky

BackgroundRight ventricular (RV) function is currently being evaluated solely according to the properties of RV myocardium. We have tested a concept that in patients with heart failure with reduced ejection fraction (HFrEF), RV assessment should integrate the information about both RV function as well as size. MethodsA total of 836 stable patients with HFrEF (LVEF 23.6 &amp; PLUSMN; 5.8%, 82.8% males, 68% NYHA III/IV) underwent echocardiographic evaluation and were prospectively followed for a median of 3.07 (IQRs 1.11; 4.89) years for the occurrence of death, urgent heart transplantation or implantation of mechanical circulatory support. ResultsRV size (measured as RV-basal diameter, RVD1) was significantly associated with an adverse outcome independent of RV dysfunction grade (p = 0.0002). The prognostic power of RVD1 was further improved by indexing to body surface area (RVD(1)i, p &lt; 0.05 compared to non-indexed value). A novel parameter named RV global dysfunction score (RVGDs) was calculated as a product of RVD(1)i and the degree of RV dysfunction (1-4 for preserved RV function, mild, moderate and severe dysfunction, respectively). RVGDs showed a superior prognostic role compared to RV dysfunction grade alone (&amp; UDelta;AUC &gt;0.03, p &lt; 0.0001). In every subgroup of RVGDs (&lt;20, 20-40, 40-60, &gt;60), patients with milder degree of RV dysfunction but more dilated RV had similar outcome as those with more severe degree of RV dysfunction but smaller RV size (all p &gt; 0.50), independent of tricuspid regurgitation severity and degree of pulmonary hypertension. ConclusionRV dilatation is a manifestation of RV dysfunction. The evaluation of RV performance should integrate the information about both RV size and function.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in cardiovascular medicine

ISSN

2297-055X

e-ISSN

2297-055X

Svazek periodika

10

Číslo periodika v rámci svazku

August 4

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

9

Strana od-do

"art. no. 1194174"

Kód UT WoS článku

001050181900001

EID výsledku v databázi Scopus

2-s2.0-85168357169