The importance of sampling time in radionuclide measurement of glomerular filtration rate in adults using single blood sample

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084250" target="_blank" >RIV/00023001:_____/23:00084250 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/23:10466821 RIV/00064165:_____/23:10466821

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s40336-023-00583-3" target="_blank" >https://link.springer.com/article/10.1007/s40336-023-00583-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s40336-023-00583-3" target="_blank" >10.1007/s40336-023-00583-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The importance of sampling time in radionuclide measurement of glomerular filtration rate in adults using single blood sample

Popis výsledku v původním jazyce

PurposeIn theory, radionuclide measurement of glomerular filtration rate (GFR) using bolus injection and a single blood sample results in GFR values close to the results of slope-intercept (SI) method using two or more blood samples, especially if the sample is collected at specific time. The aim of our study was to provide experimental validation of this assumption, to design the new single-sample methods potentially correcting for inadequate sampling time, and to validate them together with the method recommended by the British Nuclear Medicine Society (BNMS) guidelines.MethodsNew analytic and regression-based single-sample methods were developed using previously published concepts. In 373 patients, GFR measured by the new methods and by the method recommended by the BNMS guidelines was compared with the reference GFR measured by SI method using two blood samples. Prediction of the reference GFR was evaluated by cross-validation with all blood samples and with blood samples collected at time interval &amp; PLUSMN; 30 min around optimal sampling time.ResultsWith all 768 blood samples (regardless of sampling time), the method recommended by the BNMS guidelines performed significantly better than the new methods, predicting reference GFR with the mean absolute error (MAE) of 2.55 (versus 2.95-3.37) ml/min/1.73 m(2). In the subset of blood samples collected at time interval &amp; PLUSMN; 30 min around optimal sampling time derived from SI method (n = 247), performance of all methods was significantly improved. MAE was reduced to 1.18 (vs. 1.27-1.39) ml/min/1.73 m(2). Realistic estimate of optimal sampling time using creatinine prediction equation CKD-EPI (n = 235) resulted in MAE of 1.37 (vs. 1.53-1.76) ml/min/1.73 m(2).ConclusionThe study experimentally confirmed that collection of single blood sample near patient-specific optimal sampling time significantly improves accuracy of prediction of the reference SI GFR by all validated single-sample methods. The method recommended by the BNMS guidelines provided the best results with low prediction error that was further reduced by collecting blood sample at optimal sampling time. The new methods successfully corrected for small deviations from optimal sampling time.

Název v anglickém jazyce

The importance of sampling time in radionuclide measurement of glomerular filtration rate in adults using single blood sample

Popis výsledku anglicky

PurposeIn theory, radionuclide measurement of glomerular filtration rate (GFR) using bolus injection and a single blood sample results in GFR values close to the results of slope-intercept (SI) method using two or more blood samples, especially if the sample is collected at specific time. The aim of our study was to provide experimental validation of this assumption, to design the new single-sample methods potentially correcting for inadequate sampling time, and to validate them together with the method recommended by the British Nuclear Medicine Society (BNMS) guidelines.MethodsNew analytic and regression-based single-sample methods were developed using previously published concepts. In 373 patients, GFR measured by the new methods and by the method recommended by the BNMS guidelines was compared with the reference GFR measured by SI method using two blood samples. Prediction of the reference GFR was evaluated by cross-validation with all blood samples and with blood samples collected at time interval &amp; PLUSMN; 30 min around optimal sampling time.ResultsWith all 768 blood samples (regardless of sampling time), the method recommended by the BNMS guidelines performed significantly better than the new methods, predicting reference GFR with the mean absolute error (MAE) of 2.55 (versus 2.95-3.37) ml/min/1.73 m(2). In the subset of blood samples collected at time interval &amp; PLUSMN; 30 min around optimal sampling time derived from SI method (n = 247), performance of all methods was significantly improved. MAE was reduced to 1.18 (vs. 1.27-1.39) ml/min/1.73 m(2). Realistic estimate of optimal sampling time using creatinine prediction equation CKD-EPI (n = 235) resulted in MAE of 1.37 (vs. 1.53-1.76) ml/min/1.73 m(2).ConclusionThe study experimentally confirmed that collection of single blood sample near patient-specific optimal sampling time significantly improves accuracy of prediction of the reference SI GFR by all validated single-sample methods. The method recommended by the BNMS guidelines provided the best results with low prediction error that was further reduced by collecting blood sample at optimal sampling time. The new methods successfully corrected for small deviations from optimal sampling time.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

<a href="/cs/project/GA303%2F07%2F0950" target="_blank" >GA303/07/0950: Kvantitativní hodnocení dynamické scintigrafie ledvin</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical and Translational Imaging

ISSN

2281-5872

e-ISSN

2281-7565

Svazek periodika

11

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

12

Strana od-do

493-504

Kód UT WoS článku

001043657600002

EID výsledku v databázi Scopus

2-s2.0-85166911253