A novel prognostic nomogram predicts premature failure of kidney allografts with IgA nephropathy recurrence

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084318" target="_blank" >RIV/00023001:_____/23:00084318 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/23:10465993

Výsledek na webu

<a href="https://academic.oup.com/ndt/article/38/11/2627/7172144?login=true" target="_blank" >https://academic.oup.com/ndt/article/38/11/2627/7172144?login=true</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1093/ndt/gfad097" target="_blank" >10.1093/ndt/gfad097</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A novel prognostic nomogram predicts premature failure of kidney allografts with IgA nephropathy recurrence

Popis výsledku v původním jazyce

Background Recurrence of immunoglobulin A nephropathy (IgAN) limits graft survival in kidney transplantation. However, predictors of a worse outcome are poorly understood. Methods Among 442 kidney transplant recipients (KTRs) with IgAN, 83 (18.8%) KTRs exhibited biopsy-proven IgAN recurrence between 1994 and 2020 and were enrolled in the derivation cohort. A multivariable Cox model predicting allograft loss based on clinical data at the biopsy and a web-based nomogram were developed. The nomogram was externally validated using an independent cohort (n = 67). Results Patient age &lt;43 years {hazard ratio [HR] 2.20 [95% confidence interval (CI) 1.41-3.43], P &lt; .001}, female gender [HR 1.72 (95% CI 1.07-2.76), P = .026] and retransplantation status [HR 1.98 (95% CI 1.13-3.36), P = .016] were identified as independent risk factors for IgAN recurrence. Patient age &lt;43 years [HR 2.77 (95% CI 1.17-6.56), P = .02], proteinuria &gt;1 g/24 hours [HR 3.12 (95% CI 1.40-6.91), P = .005] and C4d positivity [HR 2.93 (95% CI 1.26-6.83), P = .013] were found to be associated with graft loss in patients with IgAN recurrence. A nomogram predicting graft loss was constructed based on clinical and histological variables, with a C statistic of 0.736 for the derivation cohort and 0.807 for the external validation cohort. Conclusions The established nomogram identified patients with recurrent IgAN at risk for premature graft loss with good predictive performance.

Název v anglickém jazyce

A novel prognostic nomogram predicts premature failure of kidney allografts with IgA nephropathy recurrence

Popis výsledku anglicky

Background Recurrence of immunoglobulin A nephropathy (IgAN) limits graft survival in kidney transplantation. However, predictors of a worse outcome are poorly understood. Methods Among 442 kidney transplant recipients (KTRs) with IgAN, 83 (18.8%) KTRs exhibited biopsy-proven IgAN recurrence between 1994 and 2020 and were enrolled in the derivation cohort. A multivariable Cox model predicting allograft loss based on clinical data at the biopsy and a web-based nomogram were developed. The nomogram was externally validated using an independent cohort (n = 67). Results Patient age &lt;43 years {hazard ratio [HR] 2.20 [95% confidence interval (CI) 1.41-3.43], P &lt; .001}, female gender [HR 1.72 (95% CI 1.07-2.76), P = .026] and retransplantation status [HR 1.98 (95% CI 1.13-3.36), P = .016] were identified as independent risk factors for IgAN recurrence. Patient age &lt;43 years [HR 2.77 (95% CI 1.17-6.56), P = .02], proteinuria &gt;1 g/24 hours [HR 3.12 (95% CI 1.40-6.91), P = .005] and C4d positivity [HR 2.93 (95% CI 1.26-6.83), P = .013] were found to be associated with graft loss in patients with IgAN recurrence. A nomogram predicting graft loss was constructed based on clinical and histological variables, with a C statistic of 0.736 for the derivation cohort and 0.807 for the external validation cohort. Conclusions The established nomogram identified patients with recurrent IgAN at risk for premature graft loss with good predictive performance.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nephrology, dialysis, transplantation

ISSN

0931-0509

e-ISSN

1460-2385

Svazek periodika

38

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

2627-2636

Kód UT WoS článku

001004085600001

EID výsledku v databázi Scopus

2-s2.0-85175878393