A multi-institutional report of intermediate-term kidney outcomes in uterus transplant recipients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084368" target="_blank" >RIV/00023001:_____/23:00084368 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/23:10467220 RIV/00216208:11110/23:10467220

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S2468024923014158?pes=vor" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2468024923014158?pes=vor</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ekir.2023.07.036" target="_blank" >10.1016/j.ekir.2023.07.036</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A multi-institutional report of intermediate-term kidney outcomes in uterus transplant recipients

Popis výsledku v původním jazyce

Uterus transplant (UTx) is a treatment for uterine factor infertility. Globally, the number of UTx recipients is increasing.1, 2, 3 Many recipients have Mayer-Rokitansky-Kuster-Hauser syndrome, which may include unilateral kidney agenesis in addition to a congenitally absent uterus and vaginal aplasia.4 Therefore, kidney dysfunction is a potential complication of UTx.We have previously demonstrated that UTx recipients experience a decrease in estimated glomerular filtration rate (eGFR) early posttransplant,5 that persists into the early postpartum period. We have also demonstrated that the incidence of acute kidney injury (AKI) and preeclampsia (28%) are increased.5 However, UTx is a unique transplant paradigm; after childbearing is complete, a graft hysterectomy is performed and immunosuppression is discontinued. The cumulative effect of pregnancy, AKI episodes, preeclampsia, and temporary calcineurin inhibitor (CNI) exposure on longer-term kidney function remains undefined. We undertook this study in a cohort representing most of the United States UTx population and selected participants from Europe to elucidate intermediate-term kidney outcomes among UTx recipients.

Název v anglickém jazyce

A multi-institutional report of intermediate-term kidney outcomes in uterus transplant recipients

Popis výsledku anglicky

Uterus transplant (UTx) is a treatment for uterine factor infertility. Globally, the number of UTx recipients is increasing.1, 2, 3 Many recipients have Mayer-Rokitansky-Kuster-Hauser syndrome, which may include unilateral kidney agenesis in addition to a congenitally absent uterus and vaginal aplasia.4 Therefore, kidney dysfunction is a potential complication of UTx.We have previously demonstrated that UTx recipients experience a decrease in estimated glomerular filtration rate (eGFR) early posttransplant,5 that persists into the early postpartum period. We have also demonstrated that the incidence of acute kidney injury (AKI) and preeclampsia (28%) are increased.5 However, UTx is a unique transplant paradigm; after childbearing is complete, a graft hysterectomy is performed and immunosuppression is discontinued. The cumulative effect of pregnancy, AKI episodes, preeclampsia, and temporary calcineurin inhibitor (CNI) exposure on longer-term kidney function remains undefined. We undertook this study in a cohort representing most of the United States UTx population and selected participants from Europe to elucidate intermediate-term kidney outcomes among UTx recipients.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Kidney International Reports

ISSN

2468-0249

e-ISSN

2468-0249

Svazek periodika

8

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

2156-2159

Kód UT WoS článku

001164945200001

EID výsledku v databázi Scopus

2-s2.0-85168737601