Eosinophils-from cradle to grave

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084416" target="_blank" >RIV/00023001:_____/23:00084416 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/23:10469070 RIV/00216208:11110/23:10469070 RIV/00064203:_____/23:10469070 RIV/00064190:_____/23:10001176

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.15884" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1111/all.15884</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/all.15884" target="_blank" >10.1111/all.15884</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Eosinophils-from cradle to grave

Popis výsledku v původním jazyce

Over the past years, eosinophils have become a focus of scientific interest, especially in the context of their recently uncovered functions (e.g. antiviral, anti-inflammatory, regulatory). These versatile cells display both beneficial and detrimental activities under various physiological and pathological conditions. Eosinophils are involved in the pathogenesis of many diseases which can be classified into primary (clonal) and secondary (reactive) disorders and idiopathic (hyper)eosinophilic syndromes. Depending on the biological specimen, the eosinophil count in different body compartments may serve as a biomarker reflecting the underlying pathophysiology and/or activity of distinct diseases and as a therapy-driving (predictive) and monitoring tool. Personalized selection of an appropriate therapeutic strategy directly or indirectly targeting the increased number and/or activity of eosinophils should be based on the understanding of eosinophil homeostasis including their interactions with other immune and non-immune cells within different body compartments. Hence, restoring as well as maintaining homeostasis within an individual&apos;s eosinophil pool is a goal of both specific and non-specific eosinophil-targeting therapies. Despite the overall favourable safety profile of the currently available anti-eosinophil biologics, the effect of eosinophil depletion should be monitored from the perspective of possible unwanted consequences.

Název v anglickém jazyce

Eosinophils-from cradle to grave

Popis výsledku anglicky

Over the past years, eosinophils have become a focus of scientific interest, especially in the context of their recently uncovered functions (e.g. antiviral, anti-inflammatory, regulatory). These versatile cells display both beneficial and detrimental activities under various physiological and pathological conditions. Eosinophils are involved in the pathogenesis of many diseases which can be classified into primary (clonal) and secondary (reactive) disorders and idiopathic (hyper)eosinophilic syndromes. Depending on the biological specimen, the eosinophil count in different body compartments may serve as a biomarker reflecting the underlying pathophysiology and/or activity of distinct diseases and as a therapy-driving (predictive) and monitoring tool. Personalized selection of an appropriate therapeutic strategy directly or indirectly targeting the increased number and/or activity of eosinophils should be based on the understanding of eosinophil homeostasis including their interactions with other immune and non-immune cells within different body compartments. Hence, restoring as well as maintaining homeostasis within an individual&apos;s eosinophil pool is a goal of both specific and non-specific eosinophil-targeting therapies. Despite the overall favourable safety profile of the currently available anti-eosinophil biologics, the effect of eosinophil depletion should be monitored from the perspective of possible unwanted consequences.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Allergy

ISSN

0105-4538

e-ISSN

1398-9995

Svazek periodika

78

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

DK - Dánské království

Počet stran výsledku

26

Strana od-do

3077-3102

Kód UT WoS článku

001068244800001

EID výsledku v databázi Scopus

2-s2.0-85170692420