Extracorporeal cardiopulmonary resuscitation-based approach to refractory out-of-hospital cardiac arrest: a focus on organ donation, a secondary analysis of a Prague OHCA randomized study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084430" target="_blank" >RIV/00023001:_____/23:00084430 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21730/23:00370271 RIV/00216208:11110/23:10474021 RIV/00064165:_____/23:10474021

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0300957223003076" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0300957223003076</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.resuscitation.2023.109993" target="_blank" >10.1016/j.resuscitation.2023.109993</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Extracorporeal cardiopulmonary resuscitation-based approach to refractory out-of-hospital cardiac arrest: a focus on organ donation, a secondary analysis of a Prague OHCA randomized study

Popis výsledku v původním jazyce

Background: Refractory out-of-hospital cardiac arrest (OHCA) has a poor outcome. In patients, who cannot be rescued despite using advanced techniques like extracorporeal cardiopulmonary resuscitation (ECPR), organ donation may be considered. This study aims to evaluate, in refractory OHCA, how ECPR versus a standard-based approach allows organ donorship. Methods: The Prague OHCA trial randomized adults with a witnessed refractory OHCA of presumed cardiac origin to either an ECPR-based or standard approach. Patients who died of brain death or those who died of primary circulatory reasons and were not candidates for cardiac transplantation or durable ventricle assist device were evaluated as potential organ donors by a transplant center. In this post-hoc analysis, the effect on organ donation rates and one-year organ survival in recipients was examined. Results: Out of 256 enrolled patients, 75 (29%) died prehospitally or within 1 hour after admission and 107 (42%) during the hospital stay. From a total of 24 considered donors, 21 and 3 (p = 0.01) were recruited from the ECPR vs standard approach arm, respectively. Fifteen brain-dead and none cardiac-dead subjects were ultimately accepted, 13 from the ECPR and two from the standard strategy group. A total of 36 organs were harvested. The organs were successfully transplanted into 34 recipients. All transplanted organs were fully functional, and none of the recipients died due to graft failure within the one-year period post-transplant. Conclusion: The ECPR-based approach in the refractory OHCA trial is associated with increased organ donorship and an excellent outcome of transplanted organs. Trial registration: ClinicalTrials.gov Identifier: NCT 01511666. Registered January 19, 2012. © 2023 The Authors

Název v anglickém jazyce

Extracorporeal cardiopulmonary resuscitation-based approach to refractory out-of-hospital cardiac arrest: a focus on organ donation, a secondary analysis of a Prague OHCA randomized study

Popis výsledku anglicky

Background: Refractory out-of-hospital cardiac arrest (OHCA) has a poor outcome. In patients, who cannot be rescued despite using advanced techniques like extracorporeal cardiopulmonary resuscitation (ECPR), organ donation may be considered. This study aims to evaluate, in refractory OHCA, how ECPR versus a standard-based approach allows organ donorship. Methods: The Prague OHCA trial randomized adults with a witnessed refractory OHCA of presumed cardiac origin to either an ECPR-based or standard approach. Patients who died of brain death or those who died of primary circulatory reasons and were not candidates for cardiac transplantation or durable ventricle assist device were evaluated as potential organ donors by a transplant center. In this post-hoc analysis, the effect on organ donation rates and one-year organ survival in recipients was examined. Results: Out of 256 enrolled patients, 75 (29%) died prehospitally or within 1 hour after admission and 107 (42%) during the hospital stay. From a total of 24 considered donors, 21 and 3 (p = 0.01) were recruited from the ECPR vs standard approach arm, respectively. Fifteen brain-dead and none cardiac-dead subjects were ultimately accepted, 13 from the ECPR and two from the standard strategy group. A total of 36 organs were harvested. The organs were successfully transplanted into 34 recipients. All transplanted organs were fully functional, and none of the recipients died due to graft failure within the one-year period post-transplant. Conclusion: The ECPR-based approach in the refractory OHCA trial is associated with increased organ donorship and an excellent outcome of transplanted organs. Trial registration: ClinicalTrials.gov Identifier: NCT 01511666. Registered January 19, 2012. © 2023 The Authors

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30221 - Critical care medicine and Emergency medicine

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Resuscitation

ISSN

0300-9572

e-ISSN

1873-1570

Svazek periodika

193

Číslo periodika v rámci svazku

December

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

8

Strana od-do

"art. no. 109993"

Kód UT WoS článku

001138791400001

EID výsledku v databázi Scopus

2-s2.0-85174466914