The impact of frailty syndrome on humoral response to SARS-CoV-2 mRNA vaccines in older kidney transplant recipients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084435" target="_blank" >RIV/00023001:_____/23:00084435 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/23:43925336

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s11255-023-03557-6" target="_blank" >https://link.springer.com/article/10.1007/s11255-023-03557-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11255-023-03557-6" target="_blank" >10.1007/s11255-023-03557-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The impact of frailty syndrome on humoral response to SARS-CoV-2 mRNA vaccines in older kidney transplant recipients

Popis výsledku v původním jazyce

Purpose: Advanced age is associated with an impaired humoral immune response to SARS-CoV-2 mRNA vaccination in kidney transplant recipients (KTR). The mechanisms are, however, poorly understood. Frailty syndrome assessment may determine the most vulnerable population. Methods: This study is a secondary analysis of a prospective study (NCT04832841) regarding seroconversion after BNT162b2 vaccination, including 101 SARS-CoV-2 naïve KTR 70 years and older. The Fried frailty components were evaluated, and antibodies against S1 and S2 subunits of SARS-CoV-2 were examined &gt; 14 days after the second dose of BNT162b2 vaccine. Results: Seroconversion was observed in 33 KTR. Male gender, eGFR, MMF-free immunosuppression, and a lower frailty score were associated with higher seroconversion rates in univariable regression. Concerning frailty components, physical inactivity had the most negative effect on seroconversion (OR = 0.36, 95% CI 0.14–0.95, p = 0.039). In a multivariable regression adjusted for eGFR, MMF-free immunosuppression, time from transplant and gender, pre-frail (OR = 0.27, 95% CI 0.07–1.00, p = 0.050), and frail status (OR = 0.14, 95% CI 0.03–0.73, p = 0.019) were associated with an increased risk of unresponsiveness to SARS-CoV-2 vaccines. Conclusion: Frailty was associated with an impaired humoral response to SARS-CoV-2 mRNA vaccination in older SARS-CoV-2 naïve KTR. Trail registration: This study is registered under the identifier NCT04832841 on ClinicalTrials.gov. © 2023, The Author(s).

Název v anglickém jazyce

The impact of frailty syndrome on humoral response to SARS-CoV-2 mRNA vaccines in older kidney transplant recipients

Popis výsledku anglicky

Purpose: Advanced age is associated with an impaired humoral immune response to SARS-CoV-2 mRNA vaccination in kidney transplant recipients (KTR). The mechanisms are, however, poorly understood. Frailty syndrome assessment may determine the most vulnerable population. Methods: This study is a secondary analysis of a prospective study (NCT04832841) regarding seroconversion after BNT162b2 vaccination, including 101 SARS-CoV-2 naïve KTR 70 years and older. The Fried frailty components were evaluated, and antibodies against S1 and S2 subunits of SARS-CoV-2 were examined &gt; 14 days after the second dose of BNT162b2 vaccine. Results: Seroconversion was observed in 33 KTR. Male gender, eGFR, MMF-free immunosuppression, and a lower frailty score were associated with higher seroconversion rates in univariable regression. Concerning frailty components, physical inactivity had the most negative effect on seroconversion (OR = 0.36, 95% CI 0.14–0.95, p = 0.039). In a multivariable regression adjusted for eGFR, MMF-free immunosuppression, time from transplant and gender, pre-frail (OR = 0.27, 95% CI 0.07–1.00, p = 0.050), and frail status (OR = 0.14, 95% CI 0.03–0.73, p = 0.019) were associated with an increased risk of unresponsiveness to SARS-CoV-2 vaccines. Conclusion: Frailty was associated with an impaired humoral response to SARS-CoV-2 mRNA vaccination in older SARS-CoV-2 naïve KTR. Trail registration: This study is registered under the identifier NCT04832841 on ClinicalTrials.gov. © 2023, The Author(s).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30217 - Urology and nephrology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International urology and nephrology

ISSN

0301-1623

e-ISSN

1573-2584

Svazek periodika

55

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

2959-2965

Kód UT WoS článku

000964079800001

EID výsledku v databázi Scopus

2-s2.0-85152052973