Sex-linked differences in cardiac atrophy after mechanical unloading induced by heterotopic heart transplantation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F23%3A00084649" target="_blank" >RIV/00023001:_____/23:00084649 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Sex-linked differences in cardiac atrophy after mechanical unloading induced by heterotopic heart transplantation

Popis výsledku v původním jazyce

There is no information about possible sex-related differences in unloading-induced cardiac atrophy. We aimedto compare the course of unloading-induced cardiac atrophy in intact (without gonadectomy) male and femalerats, and in animals after gonadectomy, in order to obtain insight into the infl uence of sex hormones on thisprocess. Heterotopic heart transplantation (HT) was usedas a model for heart unloading. Cardiac atrophy was assessed as the weight ratio of heterotopically transplantedheart weight (HW) to the native HW on days 7 and 14after HT in intact male and female rats. In separate experimental groups, gonadectomy was performed in maleand female recipient animals 28 days before HT and thecourse of cardiac atrophy was again evaluated on days 7and 14 after HT. In intact male rats, HT resulted in significantly greater decreases in whole HW when compared tointact female rats. The dynamics of the left ventricle (LV)and right ventricle (RV) atrophy after HT were quite similar to that of whole hearts. Gonadectomy did not haveany signifi cant effect on the decreases in whole HW, LV,and RV weights, with similar results in male and femalerats. Our results show that the development of unloading-induced cardiac atrophy is substantially reduced infemale rats when compared to male rats. Since gonadectomy did not alter the course of cardiac atrophy after HT,similarly in both male and female rats, we conclude thatsex-linked differences in the development of unloadinginduced cardiac atrophy are not caused by the activity ofsex hormones.

Název v anglickém jazyce

Sex-linked differences in cardiac atrophy after mechanical unloading induced by heterotopic heart transplantation

Popis výsledku anglicky

There is no information about possible sex-related differences in unloading-induced cardiac atrophy. We aimedto compare the course of unloading-induced cardiac atrophy in intact (without gonadectomy) male and femalerats, and in animals after gonadectomy, in order to obtain insight into the infl uence of sex hormones on thisprocess. Heterotopic heart transplantation (HT) was usedas a model for heart unloading. Cardiac atrophy was assessed as the weight ratio of heterotopically transplantedheart weight (HW) to the native HW on days 7 and 14after HT in intact male and female rats. In separate experimental groups, gonadectomy was performed in maleand female recipient animals 28 days before HT and thecourse of cardiac atrophy was again evaluated on days 7and 14 after HT. In intact male rats, HT resulted in significantly greater decreases in whole HW when compared tointact female rats. The dynamics of the left ventricle (LV)and right ventricle (RV) atrophy after HT were quite similar to that of whole hearts. Gonadectomy did not haveany signifi cant effect on the decreases in whole HW, LV,and RV weights, with similar results in male and femalerats. Our results show that the development of unloading-induced cardiac atrophy is substantially reduced infemale rats when compared to male rats. Since gonadectomy did not alter the course of cardiac atrophy after HT,similarly in both male and female rats, we conclude thatsex-linked differences in the development of unloadinginduced cardiac atrophy are not caused by the activity ofsex hormones.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

<a href="/cs/project/LX22NPO5104" target="_blank" >LX22NPO5104: Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů