Renal sympathetic denervation improves pressure-natriuresis relationship in cardiorenal syndrome: insight from studies with Ren-2 transgenic hypertensive rats with volume overload induced using aorto-caval fistula

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00084698" target="_blank" >RIV/00023001:_____/24:00084698 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/24:43926617 RIV/00098892:_____/24:10158454

Výsledek na webu

<a href="https://www.nature.com/articles/s41440-024-01583-0.pdf" target="_blank" >https://www.nature.com/articles/s41440-024-01583-0.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41440-024-01583-0" target="_blank" >10.1038/s41440-024-01583-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Renal sympathetic denervation improves pressure-natriuresis relationship in cardiorenal syndrome: insight from studies with Ren-2 transgenic hypertensive rats with volume overload induced using aorto-caval fistula

Popis výsledku v původním jazyce

The aim was to evaluate the effects of renal denervation (RDN) on autoregulation of renal hemodynamics and the pressure-natriuresis relationship in Ren-2 transgenic rats (TGR) with aorto-caval fistula (ACF)-induced heart failure (HF). RDN was performed one week after creation of ACF or sham-operation. Animals were prepared for evaluation of autoregulatory capacity of renal blood flow (RBF) and glomerular filtration rate (GFR), and of the pressure-natriuresis characteristics after stepwise changes in renal arterial pressure (RAP) induced by aortic clamping. Their basal values of blood pressure and renal function were significantly lower than with innervated sham-operated TGR (p &lt; 0.05 in all cases): mean arterial pressure (MAP) (115 +/- 2 vs. 160 +/- 3 mmHg), RBF (6.91 +/- 0.33 vs. 10.87 +/- 0.38 ml.min(-1).g(-1)), urine flow (UF) (11.3 +/- 1.79 vs. 43.17 +/- 3.24 &lt;mu&gt;l.min(-1).g(-1)) and absolute sodium excretion (UNaV) (1.08 +/- 0.27 vs, 6.38 +/- 0.76 mu mol.min(-1).g(-1)). After denervation ACF TGR showed improved autoregulation of RBF: at lowest RAP level (80 mmHg) the value was higher than in innervated ACF TGR (6.92 +/- 0.26 vs. 4.54 +/- 0.22 ml.min(-1).g(-1), p &lt; 0.05). Also, the pressure-natriuresis relationship was markedly improved after RDN: at the RAP of 80 mmHg UF equaled 4.31 +/- 0.99 vs. 0.26 +/- 0.09 &lt;mu&gt;l.min(-1).g(-1) recorded in innervated ACF TGR, UNaV was 0.31 +/- 0.05 vs. 0.04 +/- 0.01 mu mol min(-1).g(-1) (p &lt; 0.05 in all cases). In conclusion, in our model of hypertensive rat with ACF-induced HF, RDN improved autoregulatory capacity of RBF and the pressure-natriuresis relationship when measured at the stage of HF decompensation.

Název v anglickém jazyce

Renal sympathetic denervation improves pressure-natriuresis relationship in cardiorenal syndrome: insight from studies with Ren-2 transgenic hypertensive rats with volume overload induced using aorto-caval fistula

Popis výsledku anglicky

The aim was to evaluate the effects of renal denervation (RDN) on autoregulation of renal hemodynamics and the pressure-natriuresis relationship in Ren-2 transgenic rats (TGR) with aorto-caval fistula (ACF)-induced heart failure (HF). RDN was performed one week after creation of ACF or sham-operation. Animals were prepared for evaluation of autoregulatory capacity of renal blood flow (RBF) and glomerular filtration rate (GFR), and of the pressure-natriuresis characteristics after stepwise changes in renal arterial pressure (RAP) induced by aortic clamping. Their basal values of blood pressure and renal function were significantly lower than with innervated sham-operated TGR (p &lt; 0.05 in all cases): mean arterial pressure (MAP) (115 +/- 2 vs. 160 +/- 3 mmHg), RBF (6.91 +/- 0.33 vs. 10.87 +/- 0.38 ml.min(-1).g(-1)), urine flow (UF) (11.3 +/- 1.79 vs. 43.17 +/- 3.24 &lt;mu&gt;l.min(-1).g(-1)) and absolute sodium excretion (UNaV) (1.08 +/- 0.27 vs, 6.38 +/- 0.76 mu mol.min(-1).g(-1)). After denervation ACF TGR showed improved autoregulation of RBF: at lowest RAP level (80 mmHg) the value was higher than in innervated ACF TGR (6.92 +/- 0.26 vs. 4.54 +/- 0.22 ml.min(-1).g(-1), p &lt; 0.05). Also, the pressure-natriuresis relationship was markedly improved after RDN: at the RAP of 80 mmHg UF equaled 4.31 +/- 0.99 vs. 0.26 +/- 0.09 &lt;mu&gt;l.min(-1).g(-1) recorded in innervated ACF TGR, UNaV was 0.31 +/- 0.05 vs. 0.04 +/- 0.01 mu mol min(-1).g(-1) (p &lt; 0.05 in all cases). In conclusion, in our model of hypertensive rat with ACF-induced HF, RDN improved autoregulatory capacity of RBF and the pressure-natriuresis relationship when measured at the stage of HF decompensation.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Hypertension research

ISSN

0916-9636

e-ISSN

1348-4214

Svazek periodika

47

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

19

Strana od-do

"998–1016"

Kód UT WoS článku

001154951600001

EID výsledku v databázi Scopus

2-s2.0-85183725394