Increase in lumbar spine but not distal radius bone mineral density in adults after pancreas kidney transplantation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00084909" target="_blank" >RIV/00023001:_____/24:00084909 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11130/24:10479730 RIV/00216208:11320/24:10479730 RIV/00064203:_____/24:10479730

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S2352187224000317?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2352187224000317?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bonr.2024.101764" target="_blank" >10.1016/j.bonr.2024.101764</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Increase in lumbar spine but not distal radius bone mineral density in adults after pancreas kidney transplantation

Popis výsledku v původním jazyce

Osteoporosis occurs in every third individual after simultaneous pancreas kidney transplantation (SPKT). Currently used bone measures insufficiently predict their fracture risk. Lumbar spine Trabecular bone score (TBS) and distal radius areal and volumetric bone mineral density (BMD) were monitored for the first time in patients with type 1 diabetes and chronic renal failure after SPKT with steroid-sparing protocol. In 33 subjects (mean age 43.4 +/- 9.8 years), dual-energy X-ray absorptiometry and peripheral quantitative computed tomography were performed just after SPKT (baseline) and one and three years later. While TBS Z-scores increased (-1.1 +/- 1.2 and -0.3 +/- 1.0; p &lt; 0.001, at baseline and year three, respectively), trabecular volumetric BMD Z-scores at distal radius metaphysis did not change during the study (-1.3 +/- 1.3 and-1.3 +/- 1.0; p = 0.38). Similarly, areal BMD Z-scores increased at lumbar spine, total hip and femoral neck (all p &lt; 0.01), but not at the distal radius. SPKT induced bone measures &apos;improvement at lumbar spine and hip but not at distal radius. Before suggesting changes in current clinical care, predictive value of individual bone measures or its combination for fracture risk assessment remains to be elucidated.

Název v anglickém jazyce

Increase in lumbar spine but not distal radius bone mineral density in adults after pancreas kidney transplantation

Popis výsledku anglicky

Osteoporosis occurs in every third individual after simultaneous pancreas kidney transplantation (SPKT). Currently used bone measures insufficiently predict their fracture risk. Lumbar spine Trabecular bone score (TBS) and distal radius areal and volumetric bone mineral density (BMD) were monitored for the first time in patients with type 1 diabetes and chronic renal failure after SPKT with steroid-sparing protocol. In 33 subjects (mean age 43.4 +/- 9.8 years), dual-energy X-ray absorptiometry and peripheral quantitative computed tomography were performed just after SPKT (baseline) and one and three years later. While TBS Z-scores increased (-1.1 +/- 1.2 and -0.3 +/- 1.0; p &lt; 0.001, at baseline and year three, respectively), trabecular volumetric BMD Z-scores at distal radius metaphysis did not change during the study (-1.3 +/- 1.3 and-1.3 +/- 1.0; p = 0.38). Similarly, areal BMD Z-scores increased at lumbar spine, total hip and femoral neck (all p &lt; 0.01), but not at the distal radius. SPKT induced bone measures &apos;improvement at lumbar spine and hip but not at distal radius. Before suggesting changes in current clinical care, predictive value of individual bone measures or its combination for fracture risk assessment remains to be elucidated.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bone reports

ISSN

2352-1872

e-ISSN

—

Svazek periodika

21

Číslo periodika v rámci svazku

June 2024

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

"art. no. 101764"

Kód UT WoS článku

001232594900001

EID výsledku v databázi Scopus

2-s2.0-85190781371