Association between FTO polymorphism and COVID-19 mortality among older adults: a population-based cohort study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00085096" target="_blank" >RIV/00023001:_____/24:00085096 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/24:00137283 RIV/00216208:11110/24:10486271 RIV/75010330:_____/24:00014732

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1201971224003035?via%3Dihub#sec0008" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1201971224003035?via%3Dihub#sec0008</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijid.2024.107232" target="_blank" >10.1016/j.ijid.2024.107232</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Association between FTO polymorphism and COVID-19 mortality among older adults: a population-based cohort study

Popis výsledku v původním jazyce

Objectives: COVID-19 caused a global pandemic with millions of deaths. Fat mass and obesity-associated gene (FTO) FTO ) (alias m6A 6 A RNA demethylase) and its functional rs17817449 polymorphism are candidates influence COVID-19-associated mortality since methylation status of viral nucleic acids is an important factor influencing viral viability. Methods: We tested a population-based cohort of 5233 subjects (aged 63-87 years in 2020) where persons died from COVID-19 and 394 from other causes during the pandemic period. Results: The frequency of GG homozygotes was higher among those who died from COVID-19 (34%) among survivors (19%) or deaths from other causes (20%), P &lt; 0.005. After multiple adjustments, GG mozygotes had a higher risk of death from COVID-19 with odds ratio = 2.01 (95% confidence interval; 1.19-3.41, P &lt; 0.01) compared with carriers of at least one T allele. The FTO polymorphism was not ciated with mortality from other causes. Conclusions: Our results suggest that FTO variability is a significant predictor of COVID-19-associated mortality in Caucasians.&lt;br /&gt; (c) 2024 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )

Název v anglickém jazyce

Association between FTO polymorphism and COVID-19 mortality among older adults: a population-based cohort study

Popis výsledku anglicky

Objectives: COVID-19 caused a global pandemic with millions of deaths. Fat mass and obesity-associated gene (FTO) FTO ) (alias m6A 6 A RNA demethylase) and its functional rs17817449 polymorphism are candidates influence COVID-19-associated mortality since methylation status of viral nucleic acids is an important factor influencing viral viability. Methods: We tested a population-based cohort of 5233 subjects (aged 63-87 years in 2020) where persons died from COVID-19 and 394 from other causes during the pandemic period. Results: The frequency of GG homozygotes was higher among those who died from COVID-19 (34%) among survivors (19%) or deaths from other causes (20%), P &lt; 0.005. After multiple adjustments, GG mozygotes had a higher risk of death from COVID-19 with odds ratio = 2.01 (95% confidence interval; 1.19-3.41, P &lt; 0.01) compared with carriers of at least one T allele. The FTO polymorphism was not ciated with mortality from other causes. Conclusions: Our results suggest that FTO variability is a significant predictor of COVID-19-associated mortality in Caucasians.&lt;br /&gt; (c) 2024 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30303 - Infectious Diseases

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International journal of infectious diseases

ISSN

1201-9712

e-ISSN

1878-3511

Svazek periodika

148

Číslo periodika v rámci svazku

November 2024

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

"art. no. 107232"

Kód UT WoS článku

001321339500001

EID výsledku v databázi Scopus

2-s2.0-85204425539