Acute kidney injury in deceased organ donors: risk factors and impacts on transplantation outcomes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F24%3A00085219" target="_blank" >RIV/00023001:_____/24:00085219 - isvavai.cz</a>

Výsledek na webu

<a href="https://journals.lww.com/transplantationdirect/fulltext/2024/12000/acute_kidney_injury_in_deceased_organ_donors__risk.6.aspx" target="_blank" >https://journals.lww.com/transplantationdirect/fulltext/2024/12000/acute_kidney_injury_in_deceased_organ_donors__risk.6.aspx</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/TXD.0000000000001730" target="_blank" >10.1097/TXD.0000000000001730</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Acute kidney injury in deceased organ donors: risk factors and impacts on transplantation outcomes

Popis výsledku v původním jazyce

Background.Acute kidney injury in deceased donors (D-AKI) is one of the common causes of donor kidney discard. The risk factors for D-AKI and its impact on kidney transplantation outcomes are not yet fully understood. Methods.This single-center, retrospective cohort study included 388 donors referred between June 2021 and December 2022. D-AKI was defined and staged according to kidney disease: Improving global outcomes criteria, and donor clinical variables were analyzed to identify risk factors for D-AKI. Delayed graft function and estimated glomerular filtration rate (eGFR) at 6 mo were evaluated in 369 kidney grafts transplanted from donors with and without D-AKI. Results.AKI was present in 171 deceased donors (44.1%), with 117 (30.2%) classified as AKI stage 1 and 54 (14%) as AKI stages 2 or 3. Donor history of hypertension (odds ratio [OR] 1.93; 95% confidence interval [CI], 1.21-3.10; P = 0.005), history of diabetes (OR 2.2; 95% CI, 1.21-3.98; P = 0.008), and anoxia as the cause of death (OR 2.61; 95% CI, 1.5-4.61; P &lt; 0.001) were independently associated with an increased risk of D-AKI. Multivariable mixed models identified donor age (beta -0.49; 95% CI, -0.71 to -0.28; P &lt; 0.001) as the only independent risk factor for lower eGFR at 6 mo. D-AKI was not associated with delayed graft function or lower eGFR at 6 mo. Conclusions.Hypertension, diabetes, and anoxia as the cause of death were identified as risk factors for AKI in deceased donors. D-AKI should not be used as the sole criterion to assess the risk of poor graft outcomes. A broader range of donor variables should be considered when evaluating graft viability.

Název v anglickém jazyce

Acute kidney injury in deceased organ donors: risk factors and impacts on transplantation outcomes

Popis výsledku anglicky

Background.Acute kidney injury in deceased donors (D-AKI) is one of the common causes of donor kidney discard. The risk factors for D-AKI and its impact on kidney transplantation outcomes are not yet fully understood. Methods.This single-center, retrospective cohort study included 388 donors referred between June 2021 and December 2022. D-AKI was defined and staged according to kidney disease: Improving global outcomes criteria, and donor clinical variables were analyzed to identify risk factors for D-AKI. Delayed graft function and estimated glomerular filtration rate (eGFR) at 6 mo were evaluated in 369 kidney grafts transplanted from donors with and without D-AKI. Results.AKI was present in 171 deceased donors (44.1%), with 117 (30.2%) classified as AKI stage 1 and 54 (14%) as AKI stages 2 or 3. Donor history of hypertension (odds ratio [OR] 1.93; 95% confidence interval [CI], 1.21-3.10; P = 0.005), history of diabetes (OR 2.2; 95% CI, 1.21-3.98; P = 0.008), and anoxia as the cause of death (OR 2.61; 95% CI, 1.5-4.61; P &lt; 0.001) were independently associated with an increased risk of D-AKI. Multivariable mixed models identified donor age (beta -0.49; 95% CI, -0.71 to -0.28; P &lt; 0.001) as the only independent risk factor for lower eGFR at 6 mo. D-AKI was not associated with delayed graft function or lower eGFR at 6 mo. Conclusions.Hypertension, diabetes, and anoxia as the cause of death were identified as risk factors for AKI in deceased donors. D-AKI should not be used as the sole criterion to assess the risk of poor graft outcomes. A broader range of donor variables should be considered when evaluating graft viability.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30213 - Transplantation

Projekt

<a href="/cs/project/NU21-06-00021" target="_blank" >NU21-06-00021: Molekulární markery akutního poškození ledvin u zemřelých dárců vyššího věku</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Transplantation Direct

ISSN

2373-8731

e-ISSN

2373-8731

Svazek periodika

10

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

"art. no. e1730"

Kód UT WoS článku

001354615300004

EID výsledku v databázi Scopus

2-s2.0-85210359355