PNPLA3 I148M variant is the main driver of weight gain after hepatitis C cure

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F25%3A00085749" target="_blank" >RIV/00023001:_____/25:00085749 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10499832 RIV/00216208:11120/25:43928645

Výsledek na webu

<a href="https://www.nature.com/articles/s41598-025-11085-9.pdf" target="_blank" >https://www.nature.com/articles/s41598-025-11085-9.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s41598-025-11085-9" target="_blank" >10.1038/s41598-025-11085-9</a>

Jazyk výsledku

angličtina

Název v původním jazyce

PNPLA3 I148M variant is the main driver of weight gain after hepatitis C cure

Popis výsledku v původním jazyce

BMI increase is commonly described in patients after chronic hepatitis C (HCV) cure with direct-acting antivirals. The aims of our study were to confirm the BMI increase compared with a population control group and to search for the allelic association between BMI increase and PNPLA3 gene I148M variant (G allele) carriage. We compared the BMI increase in 230 patients (HCV group) 3 years after the end of anti-HCV treatment with a group of 640 healthy subjects (controls) within the same period. The median BMI increase in the HCV group was 0.39 (range - 6.5-11.8), 0.70 in controls (-6.3 - 14.0); the difference was not significant (p = 0.95). However, the HCV subgroups showed significant difference according to PNPLA3 genotype: CC 0.0 (-6.5-8.7) vs. CG + GG 0.94 (-4.2-11.8), p = 0.0045, in contrast to the subgroups of controls: CC 0.7 (-5.1-13.7) vs. CG + GG 0.7 (-0.3-14.90), p = 0.86. BMI increase in the HCV subgroup CC + CG was significantly higher than in the entire control group (p = 0.035), whereas the HCV subgroup CC did not differ from controls (p = 0.07). The BMI increase was associated with PNPLA3 G allele carriage in the allelic model and the multivariate analysis.

Název v anglickém jazyce

PNPLA3 I148M variant is the main driver of weight gain after hepatitis C cure

Popis výsledku anglicky

BMI increase is commonly described in patients after chronic hepatitis C (HCV) cure with direct-acting antivirals. The aims of our study were to confirm the BMI increase compared with a population control group and to search for the allelic association between BMI increase and PNPLA3 gene I148M variant (G allele) carriage. We compared the BMI increase in 230 patients (HCV group) 3 years after the end of anti-HCV treatment with a group of 640 healthy subjects (controls) within the same period. The median BMI increase in the HCV group was 0.39 (range - 6.5-11.8), 0.70 in controls (-6.3 - 14.0); the difference was not significant (p = 0.95). However, the HCV subgroups showed significant difference according to PNPLA3 genotype: CC 0.0 (-6.5-8.7) vs. CG + GG 0.94 (-4.2-11.8), p = 0.0045, in contrast to the subgroups of controls: CC 0.7 (-5.1-13.7) vs. CG + GG 0.7 (-0.3-14.90), p = 0.86. BMI increase in the HCV subgroup CC + CG was significantly higher than in the entire control group (p = 0.035), whereas the HCV subgroup CC did not differ from controls (p = 0.07). The BMI increase was associated with PNPLA3 G allele carriage in the allelic model and the multivariate analysis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10700 - Other natural sciences

Projekt

<a href="/cs/project/LX22NPO5104" target="_blank" >LX22NPO5104: Národní institut pro výzkum metabolických a kardiovaskulárních onemocnění</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific reports

ISSN

2045-2322

e-ISSN

2045-2322

Svazek periodika

15

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

"art. no. 25543"

Kód UT WoS článku

001530021400025

EID výsledku v databázi Scopus

2-s2.0-105010596523