Life Expectancy of Transplanted Livers: HOPE Against Aging?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023001%3A_____%2F25%3A00085891" target="_blank" >RIV/00023001:_____/25:00085891 - isvavai.cz</a>

Výsledek na webu

<a href="https://journals.lww.com/annalsofsurgery/fulltext/2025/11000/life_expectancy_of_transplanted_livers__hope.13.aspx" target="_blank" >https://journals.lww.com/annalsofsurgery/fulltext/2025/11000/life_expectancy_of_transplanted_livers__hope.13.aspx</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/SLA.0000000000006883" target="_blank" >10.1097/SLA.0000000000006883</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Life Expectancy of Transplanted Livers: HOPE Against Aging?

Popis výsledku v původním jazyce

Objective: To investigate the impact of cumulative liver age on graft survival in liver transplant recipients. Background: Organ shortage has led to increased use of elderly donor livers for an ageing group of recipients, particularly in Europe. We hypothesized that hypothermic oxygenated perfusion (HOPE) enhances graft resilience against aging in livers from elderly donors. Methods: This post hoc analysis of the multicenter European HOPE-REAL study (NCT05520320) examined liver age in adult recipients of HOPE-treated brain-dead donor (DBD) livers. Cumulative liver age was defined as the sum of donor age and post-transplant graft survival. HOPE-treated DBD liver transplants were compared with a single-center control cohort of non-perfused DBD livers using propensity score matching to adjust for confounders. Results: The median cumulative liver age was significantly higher in the HOPE-treated (n=768) cohort than in the non-perfused (n=863) group (69 vs 61 years, P&lt;0.001), yet graft survival was superior in the HOPE-treated group (log-rank P&lt;0.001). After matching, cumulative liver age remained significantly higher in the HOPE group (P&lt;0.001). Multivariate analysis identified HOPE as an independent predictor of cumulative liver age (P&lt;0.001). Conclusions: HOPE treatment seems to mitigate the risks associated with transplanting elderly DBD livers, leading to excellent long-term survival in an ageing recipient population. These findings support broader adoption of HOPE to improve utilization of older donor livers and expand the donor pool.

Název v anglickém jazyce

Life Expectancy of Transplanted Livers: HOPE Against Aging?

Popis výsledku anglicky

Objective: To investigate the impact of cumulative liver age on graft survival in liver transplant recipients. Background: Organ shortage has led to increased use of elderly donor livers for an ageing group of recipients, particularly in Europe. We hypothesized that hypothermic oxygenated perfusion (HOPE) enhances graft resilience against aging in livers from elderly donors. Methods: This post hoc analysis of the multicenter European HOPE-REAL study (NCT05520320) examined liver age in adult recipients of HOPE-treated brain-dead donor (DBD) livers. Cumulative liver age was defined as the sum of donor age and post-transplant graft survival. HOPE-treated DBD liver transplants were compared with a single-center control cohort of non-perfused DBD livers using propensity score matching to adjust for confounders. Results: The median cumulative liver age was significantly higher in the HOPE-treated (n=768) cohort than in the non-perfused (n=863) group (69 vs 61 years, P&lt;0.001), yet graft survival was superior in the HOPE-treated group (log-rank P&lt;0.001). After matching, cumulative liver age remained significantly higher in the HOPE group (P&lt;0.001). Multivariate analysis identified HOPE as an independent predictor of cumulative liver age (P&lt;0.001). Conclusions: HOPE treatment seems to mitigate the risks associated with transplanting elderly DBD livers, leading to excellent long-term survival in an ageing recipient population. These findings support broader adoption of HOPE to improve utilization of older donor livers and expand the donor pool.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30212 - Surgery

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Annals of surgery

ISSN

0003-4932

e-ISSN

1528-1140

Svazek periodika

282

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

765-771

Kód UT WoS článku

001591650000015

EID výsledku v databázi Scopus

2-s2.0-105012976603