The impact of pathological conditions on carbon and nitrogen isotopic values in the bone collagen of individuals with known biographic data and medical history
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023272%3A_____%2F21%3A10135152" target="_blank" >RIV/00023272:_____/21:10135152 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60077344:_____/21:00544007 RIV/00216208:11110/21:10439314 RIV/00216208:11310/21:10439314
Výsledek na webu
<a href="https://onlinelibrary.wiley.com/doi/10.1002/oa.3022" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/oa.3022</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/oa.3022" target="_blank" >10.1002/oa.3022</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The impact of pathological conditions on carbon and nitrogen isotopic values in the bone collagen of individuals with known biographic data and medical history
Popis výsledku v původním jazyce
This study aimed to refine our understanding of the extent to which chronic diseases with and without skeletal manifestation affect the isotopic values in bone collagen. Carbon and nitrogen isotopic values were measured in the ribs and femurs of 65 individuals from a documented skeletal collection (19th-21st centuries, Czech Republic). Statistically significant differences in both carbon and nitrogen isotopic values were found between particular families. There was a notable effect of the year of death on nitrogen isotopic values in ribs. Neither the presence of chronic disease in general nor the presence of carcinoma, age-related physical debility, or tuberculosis had a significant impact on isotopic values. Cases of cancer with skeletal metastases however showed an increase of 1 parts per thousand-1.5 parts per thousand in nitrogen isotopic values in (i) metastasis tissue, (ii) the healthy areas of bone affected by the metastasis, and (iii) the healthy rib bone. The results demonstrate that distinct dietary habits in particular families are the main driving force affecting the isotopic values in the sampled individuals. A minor but notable temporal shift in the nitrogen isotopic values of ribs may be linked to environmental and/or societal changes during the studied period. The observed increase in the nitrogen isotopic values of individuals with bone cancer metastases is in accordance with the state of cachexia and negative nitrogen balance. Despite the low number of cases, this result urges caution, as isotopic changes to the observed degree may significantly affect the dietary interpretation of the isotopic data.
Název v anglickém jazyce
The impact of pathological conditions on carbon and nitrogen isotopic values in the bone collagen of individuals with known biographic data and medical history
Popis výsledku anglicky
This study aimed to refine our understanding of the extent to which chronic diseases with and without skeletal manifestation affect the isotopic values in bone collagen. Carbon and nitrogen isotopic values were measured in the ribs and femurs of 65 individuals from a documented skeletal collection (19th-21st centuries, Czech Republic). Statistically significant differences in both carbon and nitrogen isotopic values were found between particular families. There was a notable effect of the year of death on nitrogen isotopic values in ribs. Neither the presence of chronic disease in general nor the presence of carcinoma, age-related physical debility, or tuberculosis had a significant impact on isotopic values. Cases of cancer with skeletal metastases however showed an increase of 1 parts per thousand-1.5 parts per thousand in nitrogen isotopic values in (i) metastasis tissue, (ii) the healthy areas of bone affected by the metastasis, and (iii) the healthy rib bone. The results demonstrate that distinct dietary habits in particular families are the main driving force affecting the isotopic values in the sampled individuals. A minor but notable temporal shift in the nitrogen isotopic values of ribs may be linked to environmental and/or societal changes during the studied period. The observed increase in the nitrogen isotopic values of individuals with bone cancer metastases is in accordance with the state of cachexia and negative nitrogen balance. Despite the low number of cases, this result urges caution, as isotopic changes to the observed degree may significantly affect the dietary interpretation of the isotopic data.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10620 - Other biological topics
Návaznosti výsledku
Projekt
<a href="/cs/project/GA19-13265S" target="_blank" >GA19-13265S: Zpřesnění rekonstrukce stravy minulých populací na příkladu středověké Moravy</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
International Journal of Osteoarchaeology
ISSN
1047-482X
e-ISSN
—
Svazek periodika
31
Číslo periodika v rámci svazku
6
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
20
Strana od-do
1105-1124
Kód UT WoS článku
000670611200001
EID výsledku v databázi Scopus
—