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The impact of pathological conditions on carbon and nitrogen isotopic values in the bone collagen of individuals with known biographic data and medical history

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023272%3A_____%2F21%3A10135152" target="_blank" >RIV/00023272:_____/21:10135152 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/60077344:_____/21:00544007 RIV/00216208:11110/21:10439314 RIV/00216208:11310/21:10439314

  • Výsledek na webu

    <a href="https://onlinelibrary.wiley.com/doi/10.1002/oa.3022" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/oa.3022</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/oa.3022" target="_blank" >10.1002/oa.3022</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    The impact of pathological conditions on carbon and nitrogen isotopic values in the bone collagen of individuals with known biographic data and medical history

  • Popis výsledku v původním jazyce

    This study aimed to refine our understanding of the extent to which chronic diseases with and without skeletal manifestation affect the isotopic values in bone collagen. Carbon and nitrogen isotopic values were measured in the ribs and femurs of 65 individuals from a documented skeletal collection (19th-21st centuries, Czech Republic). Statistically significant differences in both carbon and nitrogen isotopic values were found between particular families. There was a notable effect of the year of death on nitrogen isotopic values in ribs. Neither the presence of chronic disease in general nor the presence of carcinoma, age-related physical debility, or tuberculosis had a significant impact on isotopic values. Cases of cancer with skeletal metastases however showed an increase of 1 parts per thousand-1.5 parts per thousand in nitrogen isotopic values in (i) metastasis tissue, (ii) the healthy areas of bone affected by the metastasis, and (iii) the healthy rib bone. The results demonstrate that distinct dietary habits in particular families are the main driving force affecting the isotopic values in the sampled individuals. A minor but notable temporal shift in the nitrogen isotopic values of ribs may be linked to environmental and/or societal changes during the studied period. The observed increase in the nitrogen isotopic values of individuals with bone cancer metastases is in accordance with the state of cachexia and negative nitrogen balance. Despite the low number of cases, this result urges caution, as isotopic changes to the observed degree may significantly affect the dietary interpretation of the isotopic data.

  • Název v anglickém jazyce

    The impact of pathological conditions on carbon and nitrogen isotopic values in the bone collagen of individuals with known biographic data and medical history

  • Popis výsledku anglicky

    This study aimed to refine our understanding of the extent to which chronic diseases with and without skeletal manifestation affect the isotopic values in bone collagen. Carbon and nitrogen isotopic values were measured in the ribs and femurs of 65 individuals from a documented skeletal collection (19th-21st centuries, Czech Republic). Statistically significant differences in both carbon and nitrogen isotopic values were found between particular families. There was a notable effect of the year of death on nitrogen isotopic values in ribs. Neither the presence of chronic disease in general nor the presence of carcinoma, age-related physical debility, or tuberculosis had a significant impact on isotopic values. Cases of cancer with skeletal metastases however showed an increase of 1 parts per thousand-1.5 parts per thousand in nitrogen isotopic values in (i) metastasis tissue, (ii) the healthy areas of bone affected by the metastasis, and (iii) the healthy rib bone. The results demonstrate that distinct dietary habits in particular families are the main driving force affecting the isotopic values in the sampled individuals. A minor but notable temporal shift in the nitrogen isotopic values of ribs may be linked to environmental and/or societal changes during the studied period. The observed increase in the nitrogen isotopic values of individuals with bone cancer metastases is in accordance with the state of cachexia and negative nitrogen balance. Despite the low number of cases, this result urges caution, as isotopic changes to the observed degree may significantly affect the dietary interpretation of the isotopic data.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    10620 - Other biological topics

Návaznosti výsledku

  • Projekt

    <a href="/cs/project/GA19-13265S" target="_blank" >GA19-13265S: Zpřesnění rekonstrukce stravy minulých populací na příkladu středověké Moravy</a><br>

  • Návaznosti

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Ostatní

  • Rok uplatnění

    2021

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    International Journal of Osteoarchaeology

  • ISSN

    1047-482X

  • e-ISSN

  • Svazek periodika

    31

  • Číslo periodika v rámci svazku

    6

  • Stát vydavatele periodika

    US - Spojené státy americké

  • Počet stran výsledku

    20

  • Strana od-do

    1105-1124

  • Kód UT WoS článku

    000670611200001

  • EID výsledku v databázi Scopus