Supernatant versus exosomal urinary microRNAs. Two fractions with different outcomes in gynaecological cancers   

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F16%3AN0000021" target="_blank" >RIV/00023698:_____/16:N0000021 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/16:00090478 RIV/00216208:11110/16:10325175 RIV/00216208:11120/16:43912495 RIV/65269705:_____/16:00065338 RIV/00064165:_____/16:10325175

Výsledek na webu

<a href="http://dx.doi.org/10.4149/neo_2016_015" target="_blank" >http://dx.doi.org/10.4149/neo_2016_015</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4149/neo_2016_015" target="_blank" >10.4149/neo_2016_015</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Supernatant versus exosomal urinary microRNAs. Two fractions with different outcomes in gynaecological cancers   

Popis výsledku v původním jazyce

MicroRNAs (miRNAs) are key regulatory molecules implicated in fundamental cell processes. Recent investigations have been focused to investigate their diagnostic potential also in various body fluids. Plasma and serum are widely used for these purposes. Urinary miRNAs, as the easily available type of sample, have been explored particularly in urological diseases recently. However, we have shown previously that differential expression of urinary cell-free miRNAs may be observed also in gynaecological cancers, such as ovarian and endometrial cancers. In the present article, we focus on the differences in particular urine cell-free miRNA abundance among different samples including particularly ovarian and endometrial cancers and rare gynaecological diagnoses involved in the study. Using raw abundance miRNA expression data, we confirmed significant up-regulation of miR-92a in ovarian cancer, and significant down-regulation of miR-106b in endometrial cancers. As miR-21 appeared up-regulated in the endometrial cancer similarly as in the verification process, where also miR-106b resulted in significant down-regulation in ovarian cancer, these miRNAs may be good candidates for further evaluation as novel diagnostics.

Název v anglickém jazyce

Supernatant versus exosomal urinary microRNAs. Two fractions with different outcomes in gynaecological cancers   

Popis výsledku anglicky

MicroRNAs (miRNAs) are key regulatory molecules implicated in fundamental cell processes. Recent investigations have been focused to investigate their diagnostic potential also in various body fluids. Plasma and serum are widely used for these purposes. Urinary miRNAs, as the easily available type of sample, have been explored particularly in urological diseases recently. However, we have shown previously that differential expression of urinary cell-free miRNAs may be observed also in gynaecological cancers, such as ovarian and endometrial cancers. In the present article, we focus on the differences in particular urine cell-free miRNA abundance among different samples including particularly ovarian and endometrial cancers and rare gynaecological diagnoses involved in the study. Using raw abundance miRNA expression data, we confirmed significant up-regulation of miR-92a in ovarian cancer, and significant down-regulation of miR-106b in endometrial cancers. As miR-21 appeared up-regulated in the endometrial cancer similarly as in the verification process, where also miR-106b resulted in significant down-regulation in ovarian cancer, these miRNAs may be good candidates for further evaluation as novel diagnostics.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FK - Gynekologie a porodnictví

OECD FORD obor

—

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neoplasma

ISSN

0028-2685

e-ISSN

—

Svazek periodika

63

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

12

Strana od-do

123-132

Kód UT WoS článku

000370305700015

EID výsledku v databázi Scopus

2-s2.0-84969673050