High protein intake can lead to serious hypophosphatemia and hypokalemia in growth restricted preterm newborns

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F24%3AN0000048" target="_blank" >RIV/00023698:_____/24:N0000048 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/24:43926318

Výsledek na webu

<a href="https://doi.org/10.1002/jpr3.12029" target="_blank" >https://doi.org/10.1002/jpr3.12029</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jpr3.12029" target="_blank" >10.1002/jpr3.12029</a>

Jazyk výsledku

angličtina

Název v původním jazyce

High protein intake can lead to serious hypophosphatemia and hypokalemia in growth restricted preterm newborns

Popis výsledku v původním jazyce

Objectives High protein parenteral nutrition (HPPN) in the early postnatal period is a recommended strategy for very low birth weight (VLBW) infants. However, limited data is available on electrolyte changes when HPPN strategy is utilized. We investigated the impact of HPPN on the development of hypophosphatemia and hypokalemia in preterm VLBW newborns. Methods A retrospective, single-center study investigated the levels of phosphate and potassium in VLBW infants who received HPPN (amino acids intake up to 3.5 g/kg/day) during the first week of life. Preterm infants were divided into two subgroups: appropriate for gestational age (AGA) and small for gestational age (SGA) newborns. Clinical data were obtained from hospital database and medical records. Results Overall, 170 VLBW infants were included for the study analysis: 41 SGA (mean birth weight 752 +- 39 g) and 129 AGA infants (mean birth weight 994 +- 23 g). Phosphate and potassium levels were significantly lower in the SGA infants compared to AGA infants (Phosphate: 0.97 +- 0.07 mmol/l vs. 1.44 +- 0.04 mmol/l, p < 0.001; Potassium: 3.0 +- 0.1 mmol/l vs. 3.6 +- 0.1 mmol/l, p < 0.001). Conclusions Repeated measurement of serum phosphate and potassium is recommended when HPPN strategy is utilized in preterm SGA infants where significant hypophosphatemia and hypokalemia might have serious clinical consequences.

Název v anglickém jazyce

High protein intake can lead to serious hypophosphatemia and hypokalemia in growth restricted preterm newborns

Popis výsledku anglicky

Objectives High protein parenteral nutrition (HPPN) in the early postnatal period is a recommended strategy for very low birth weight (VLBW) infants. However, limited data is available on electrolyte changes when HPPN strategy is utilized. We investigated the impact of HPPN on the development of hypophosphatemia and hypokalemia in preterm VLBW newborns. Methods A retrospective, single-center study investigated the levels of phosphate and potassium in VLBW infants who received HPPN (amino acids intake up to 3.5 g/kg/day) during the first week of life. Preterm infants were divided into two subgroups: appropriate for gestational age (AGA) and small for gestational age (SGA) newborns. Clinical data were obtained from hospital database and medical records. Results Overall, 170 VLBW infants were included for the study analysis: 41 SGA (mean birth weight 752 +- 39 g) and 129 AGA infants (mean birth weight 994 +- 23 g). Phosphate and potassium levels were significantly lower in the SGA infants compared to AGA infants (Phosphate: 0.97 +- 0.07 mmol/l vs. 1.44 +- 0.04 mmol/l, p < 0.001; Potassium: 3.0 +- 0.1 mmol/l vs. 3.6 +- 0.1 mmol/l, p < 0.001). Conclusions Repeated measurement of serum phosphate and potassium is recommended when HPPN strategy is utilized in preterm SGA infants where significant hypophosphatemia and hypokalemia might have serious clinical consequences.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

30209 - Paediatrics

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JPGN Reports

ISSN

2691-171X

e-ISSN

2691-171X

Svazek periodika

5

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

58-65

Kód UT WoS článku

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EID výsledku v databázi Scopus

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