Neonatal mortality risk of large-for-gestational-age and macrosomic live births in 15 countries, including 115.6 million nationwide linked records, 2000-2020

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023698%3A_____%2F25%3AN0000022" target="_blank" >RIV/00023698:_____/25:N0000022 - isvavai.cz</a>

Výsledek na webu

<a href="https://obgyn.onlinelibrary.wiley.com/doi/10.1111/1471-0528.17706" target="_blank" >https://obgyn.onlinelibrary.wiley.com/doi/10.1111/1471-0528.17706</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/1471-0528.17706" target="_blank" >10.1111/1471-0528.17706</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Neonatal mortality risk of large-for-gestational-age and macrosomic live births in 15 countries, including 115.6 million nationwide linked records, 2000-2020

Popis výsledku v původním jazyce

Objective: We aimed to compare the prevalence and neonatal mortality associated with large for gestational age (LGA) and macrosomia among 115.6 million live births in 15 countries, between 2000 and 2020. Design: Population-based, multi-country study. Setting: National healthcare systems. Population: Liveborn infants. Methods: We used individual-level data identified for the Vulnerable Newborn Measurement Collaboration. We calculated the prevalence and relative risk (RR) of neonatal mortality among live births born at term + LGA (>90th centile, and also >95th and >97th centiles when the data were available) versus term + appropriate for gestational age (AGA, 10th-90th centiles) and macrosomic (>= 4000, >= 4500 and >= 5000 g, regardless of gestational age) versus 2500-3999 g. INTERGROWTH 21st served as the reference population. Main outcome measures: Prevalence and neonatal mortality risks. Results: Large for gestational age was common (median prevalence 18.2%; interquartile range, IQR, 13.5%-22.0%), and overall was associated with a lower neonatal mortality risk compared with AGA (RR 0.83, 95% CI 0.77-0.89). Around one in ten babies were >= 4000 g (median prevalence 9.6% (IQR 6.4%-13.3%), with 1.2% (IQR 0.7%-2.0%) >= 4500 g and with 0.2% (IQR 0.1%-0.2%) >= 5000 g). Overall, macrosomia of >= 4000 g was not associated with increased neonatal mortality risk (RR 0.80, 95% CI 0.69-0.94); however, a higher risk was observed for birthweights of >= 4500 g (RR 1.52, 95% CI 1.10-2.11) and >= 5000 g (RR 4.54, 95% CI 2.58-7.99), compared with birthweights of 2500-3999 g, with the highest risk observed in the first 7 days of life. Conclusions: In this population, birthweight of >= 4500 g was the most useful marker for early mortality risk in big babies and could be used to guide clinical management decisions.

Název v anglickém jazyce

Neonatal mortality risk of large-for-gestational-age and macrosomic live births in 15 countries, including 115.6 million nationwide linked records, 2000-2020

Popis výsledku anglicky

Objective: We aimed to compare the prevalence and neonatal mortality associated with large for gestational age (LGA) and macrosomia among 115.6 million live births in 15 countries, between 2000 and 2020. Design: Population-based, multi-country study. Setting: National healthcare systems. Population: Liveborn infants. Methods: We used individual-level data identified for the Vulnerable Newborn Measurement Collaboration. We calculated the prevalence and relative risk (RR) of neonatal mortality among live births born at term + LGA (>90th centile, and also >95th and >97th centiles when the data were available) versus term + appropriate for gestational age (AGA, 10th-90th centiles) and macrosomic (>= 4000, >= 4500 and >= 5000 g, regardless of gestational age) versus 2500-3999 g. INTERGROWTH 21st served as the reference population. Main outcome measures: Prevalence and neonatal mortality risks. Results: Large for gestational age was common (median prevalence 18.2%; interquartile range, IQR, 13.5%-22.0%), and overall was associated with a lower neonatal mortality risk compared with AGA (RR 0.83, 95% CI 0.77-0.89). Around one in ten babies were >= 4000 g (median prevalence 9.6% (IQR 6.4%-13.3%), with 1.2% (IQR 0.7%-2.0%) >= 4500 g and with 0.2% (IQR 0.1%-0.2%) >= 5000 g). Overall, macrosomia of >= 4000 g was not associated with increased neonatal mortality risk (RR 0.80, 95% CI 0.69-0.94); however, a higher risk was observed for birthweights of >= 4500 g (RR 1.52, 95% CI 1.10-2.11) and >= 5000 g (RR 4.54, 95% CI 2.58-7.99), compared with birthweights of 2500-3999 g, with the highest risk observed in the first 7 days of life. Conclusions: In this population, birthweight of >= 4500 g was the most useful marker for early mortality risk in big babies and could be used to guide clinical management decisions.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30214 - Obstetrics and gynaecology

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

ISSN

1470-0328

e-ISSN

1471-0528

Svazek periodika

132

Číslo periodika v rámci svazku

Suppl. 8

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

S109-S120

Kód UT WoS článku

001110003000001

EID výsledku v databázi Scopus

2-s2.0-105024020953