Role of Heat Shock Protein 90 in Autoimmune Inflammatory Rheumatic Diseases

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F19%3AN0000064" target="_blank" >RIV/00023728:_____/19:N0000064 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/chapter/10.1007%2F978-3-030-02254-9_5" target="_blank" >https://link.springer.com/chapter/10.1007%2F978-3-030-02254-9_5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-030-02254-9_5" target="_blank" >10.1007/978-3-030-02254-9_5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Role of Heat Shock Protein 90 in Autoimmune Inflammatory Rheumatic Diseases

Popis výsledku v původním jazyce

Hsp90 is the most studied member of the heat shock proteins family (HSP), which are characterized by induction by increased temperature and various other types of stress. It is a highly conserved molecular chaperone that plays a significant role in many cellular processes. Hsp90 is required for the proper conformation and activation of a number of client cellular proteins, including protein kinases, transcription factors and steroid receptors that play an important role in signal transduction. It also regulates activation of innate immunity, antigen presentation, and the induction of proinflammatory cytokines and chemokines by macrophages and dendritic cells. These properties predispose Hsp90 to a potential role in the pathogenesis of autoimmune inflammatory rheumatic diseases. This article provides an overview of the available knowledge about the potential role of Hsp90 in currently studied rheumatic diseases as a promising candidate for targeted therapy or biomarker of disease activity and severity or a predictor of therapeutic response.

Název v anglickém jazyce

Role of Heat Shock Protein 90 in Autoimmune Inflammatory Rheumatic Diseases

Popis výsledku anglicky

Hsp90 is the most studied member of the heat shock proteins family (HSP), which are characterized by induction by increased temperature and various other types of stress. It is a highly conserved molecular chaperone that plays a significant role in many cellular processes. Hsp90 is required for the proper conformation and activation of a number of client cellular proteins, including protein kinases, transcription factors and steroid receptors that play an important role in signal transduction. It also regulates activation of innate immunity, antigen presentation, and the induction of proinflammatory cytokines and chemokines by macrophages and dendritic cells. These properties predispose Hsp90 to a potential role in the pathogenesis of autoimmune inflammatory rheumatic diseases. This article provides an overview of the available knowledge about the potential role of Hsp90 in currently studied rheumatic diseases as a promising candidate for targeted therapy or biomarker of disease activity and severity or a predictor of therapeutic response.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30230 - Other clinical medicine subjects

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Chaperokine Activitiy of Heat Shock Proteins

ISBN

978-3-030-02253-2

Počet stran výsledku

17

Strana od-do

105-121

Počet stran knihy

320

Název nakladatele

Springer

Místo vydání

Cham

Kód UT WoS kapitoly

—