Dose-response of hyaluronate-based viscoelastic hydrogels for the treatment of knee osteoarthrosis: a prospective, randomized, comparative clinical trial

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F20%3AN0000023" target="_blank" >RIV/00023728:_____/20:N0000023 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.minervamedica.it/en/journals/minerva-orthopedics/article.php?cod=R14Y2020N02A0045" target="_blank" >https://www.minervamedica.it/en/journals/minerva-orthopedics/article.php?cod=R14Y2020N02A0045</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.23736/S0394-3410.20.03967-3" target="_blank" >10.23736/S0394-3410.20.03967-3</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dose-response of hyaluronate-based viscoelastic hydrogels for the treatment of knee osteoarthrosis: a prospective, randomized, comparative clinical trial

Popis výsledku v původním jazyce

A hyaluronate formulation for viscosupplementation, Hymovis (HYADD 4) has been proposed for treating osteoarthritis (OA) through a single injection instead of two. This study aimed to compare the safety and performance of two different doses of a single Hymovis injection to those of Synvisc-One, a well-known single-injection formulation. ixty OA patients were prospectively recruited and randomly assigned to a single injection of Hymovis 4 mL/32mg (N.=20, age 63 +/- 9 years) or 6 mL/48 mg (N.=22, age 67 +/- 8 years), or Synvisc-One 6 mL/48 mg (N.=20, age 64 +/- 10 years), and assessed through the Western Ontario McMaster University Osteoarthritis index (WOMAC) on a monthly basis up to 6 months. Two patients treated with Synvisc-One withdrew due to injection site joint inflammation. A significant improvement in OA symptoms was observed for all study groups at all time points following injection. No significant differences were observed among the treatment groups for all the study performance and safety endpoints. One injection of Hymovis 4 mL/32 mg was as safe and effective as one injection of Synvisc-One 6 mL/48 mg and should be the preferred dosage in the treatment of symptomatic knee OA by single intra-articular injection.

Název v anglickém jazyce

Dose-response of hyaluronate-based viscoelastic hydrogels for the treatment of knee osteoarthrosis: a prospective, randomized, comparative clinical trial

Popis výsledku anglicky

A hyaluronate formulation for viscosupplementation, Hymovis (HYADD 4) has been proposed for treating osteoarthritis (OA) through a single injection instead of two. This study aimed to compare the safety and performance of two different doses of a single Hymovis injection to those of Synvisc-One, a well-known single-injection formulation. ixty OA patients were prospectively recruited and randomly assigned to a single injection of Hymovis 4 mL/32mg (N.=20, age 63 +/- 9 years) or 6 mL/48 mg (N.=22, age 67 +/- 8 years), or Synvisc-One 6 mL/48 mg (N.=20, age 64 +/- 10 years), and assessed through the Western Ontario McMaster University Osteoarthritis index (WOMAC) on a monthly basis up to 6 months. Two patients treated with Synvisc-One withdrew due to injection site joint inflammation. A significant improvement in OA symptoms was observed for all study groups at all time points following injection. No significant differences were observed among the treatment groups for all the study performance and safety endpoints. One injection of Hymovis 4 mL/32 mg was as safe and effective as one injection of Synvisc-One 6 mL/48 mg and should be the preferred dosage in the treatment of symptomatic knee OA by single intra-articular injection.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30226 - Rheumatology

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

MINERVA ORTOPEDICA E TRAUMATOLOGICA

ISSN

0026-4911

e-ISSN

1827-1707

Svazek periodika

71

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

11

Strana od-do

45-55

Kód UT WoS článku

000570207600002

EID výsledku v databázi Scopus

2-s2.0-85084213859