Decrease in serum calcitriol (but not free 25-hydroxyvitamin D) concentration in hip fracture healing
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F21%3AN0000021" target="_blank" >RIV/00023728:_____/21:N0000021 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216208:11120/21:43921121 RIV/00216208:11110/21:10422948 RIV/00064211:_____/21:W0000031
Výsledek na webu
<a href="https://doi.org/10.1007/s40618-020-01489-x" target="_blank" >https://doi.org/10.1007/s40618-020-01489-x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s40618-020-01489-x" target="_blank" >10.1007/s40618-020-01489-x</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Decrease in serum calcitriol (but not free 25-hydroxyvitamin D) concentration in hip fracture healing
Popis výsledku v původním jazyce
Objective To assess the decrease in serum calcitriol concentrations after hip fracture. Methods Serum concentrations of calcitriol, 25(OH)D, parathyroid hormone (PTH), directly measured free 25(OH)D, and indices of bone formation were measured in elderly patients with hip fracture (HF) and patients with elective hip replacement (EHR) at admission and after 7 weeks. Results A total of 45 patients with HF and 17 patients with EHR completed this prospective study. Baseline serum calcitriol levels were <= 60 pmol/l in 26% of the HF patients. After 7 weeks, they significantly decreased (p < 0.001). In patients with EHR, serum calcitriol was within the reference range in all but one patient and did not change during the 7-week recovery phase. Seven weeks after HF, a significant positive relationship was observed between the change in calcitriol and serum 25(OH)D concentration (r = 0.385, p = 0.009) and free 25(OH)D (r = 0.296, p = 0.048), and a decrease in calcitriol during recovery was associated with a decrease in serum PTH (p = 0.038). Seven weeks after HF, changes in both serum PTH and serum 25(OH)D concentrations contributed to the prediction of changes in serum calcitriol (R-2 = 0.190, p = 0.012). Conclusions Unlike patients with EHR, subjects with HF had low serum 25(OH)D and low free 25(OH)D concentrations at admission, while their serum 1,25D levels were relatively elevated. Decreases in circulating calcitriol levels in the 7 weeks following hip surgery were associated with a resolution of secondary hyperparathyroidism and low availability of free 25(OH)D.
Název v anglickém jazyce
Decrease in serum calcitriol (but not free 25-hydroxyvitamin D) concentration in hip fracture healing
Popis výsledku anglicky
Objective To assess the decrease in serum calcitriol concentrations after hip fracture. Methods Serum concentrations of calcitriol, 25(OH)D, parathyroid hormone (PTH), directly measured free 25(OH)D, and indices of bone formation were measured in elderly patients with hip fracture (HF) and patients with elective hip replacement (EHR) at admission and after 7 weeks. Results A total of 45 patients with HF and 17 patients with EHR completed this prospective study. Baseline serum calcitriol levels were <= 60 pmol/l in 26% of the HF patients. After 7 weeks, they significantly decreased (p < 0.001). In patients with EHR, serum calcitriol was within the reference range in all but one patient and did not change during the 7-week recovery phase. Seven weeks after HF, a significant positive relationship was observed between the change in calcitriol and serum 25(OH)D concentration (r = 0.385, p = 0.009) and free 25(OH)D (r = 0.296, p = 0.048), and a decrease in calcitriol during recovery was associated with a decrease in serum PTH (p = 0.038). Seven weeks after HF, changes in both serum PTH and serum 25(OH)D concentrations contributed to the prediction of changes in serum calcitriol (R-2 = 0.190, p = 0.012). Conclusions Unlike patients with EHR, subjects with HF had low serum 25(OH)D and low free 25(OH)D concentrations at admission, while their serum 1,25D levels were relatively elevated. Decreases in circulating calcitriol levels in the 7 weeks following hip surgery were associated with a resolution of secondary hyperparathyroidism and low availability of free 25(OH)D.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30202 - Endocrinology and metabolism (including diabetes, hormones)
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of endocrinological investigation
ISSN
0391-4097
e-ISSN
1720-8386
Svazek periodika
44
Číslo periodika v rámci svazku
9
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
9
Strana od-do
1847-1855
Kód UT WoS článku
000611931300002
EID výsledku v databázi Scopus
2-s2.0-85099944136