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Decrease in serum calcitriol (but not free 25-hydroxyvitamin D) concentration in hip fracture healing

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F21%3AN0000021" target="_blank" >RIV/00023728:_____/21:N0000021 - isvavai.cz</a>

  • Nalezeny alternativní kódy

    RIV/00216208:11120/21:43921121 RIV/00216208:11110/21:10422948 RIV/00064211:_____/21:W0000031

  • Výsledek na webu

    <a href="https://doi.org/10.1007/s40618-020-01489-x" target="_blank" >https://doi.org/10.1007/s40618-020-01489-x</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1007/s40618-020-01489-x" target="_blank" >10.1007/s40618-020-01489-x</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Decrease in serum calcitriol (but not free 25-hydroxyvitamin D) concentration in hip fracture healing

  • Popis výsledku v původním jazyce

    Objective To assess the decrease in serum calcitriol concentrations after hip fracture. Methods Serum concentrations of calcitriol, 25(OH)D, parathyroid hormone (PTH), directly measured free 25(OH)D, and indices of bone formation were measured in elderly patients with hip fracture (HF) and patients with elective hip replacement (EHR) at admission and after 7 weeks. Results A total of 45 patients with HF and 17 patients with EHR completed this prospective study. Baseline serum calcitriol levels were <= 60 pmol/l in 26% of the HF patients. After 7 weeks, they significantly decreased (p < 0.001). In patients with EHR, serum calcitriol was within the reference range in all but one patient and did not change during the 7-week recovery phase. Seven weeks after HF, a significant positive relationship was observed between the change in calcitriol and serum 25(OH)D concentration (r = 0.385, p = 0.009) and free 25(OH)D (r = 0.296, p = 0.048), and a decrease in calcitriol during recovery was associated with a decrease in serum PTH (p = 0.038). Seven weeks after HF, changes in both serum PTH and serum 25(OH)D concentrations contributed to the prediction of changes in serum calcitriol (R-2 = 0.190, p = 0.012). Conclusions Unlike patients with EHR, subjects with HF had low serum 25(OH)D and low free 25(OH)D concentrations at admission, while their serum 1,25D levels were relatively elevated. Decreases in circulating calcitriol levels in the 7 weeks following hip surgery were associated with a resolution of secondary hyperparathyroidism and low availability of free 25(OH)D.

  • Název v anglickém jazyce

    Decrease in serum calcitriol (but not free 25-hydroxyvitamin D) concentration in hip fracture healing

  • Popis výsledku anglicky

    Objective To assess the decrease in serum calcitriol concentrations after hip fracture. Methods Serum concentrations of calcitriol, 25(OH)D, parathyroid hormone (PTH), directly measured free 25(OH)D, and indices of bone formation were measured in elderly patients with hip fracture (HF) and patients with elective hip replacement (EHR) at admission and after 7 weeks. Results A total of 45 patients with HF and 17 patients with EHR completed this prospective study. Baseline serum calcitriol levels were <= 60 pmol/l in 26% of the HF patients. After 7 weeks, they significantly decreased (p < 0.001). In patients with EHR, serum calcitriol was within the reference range in all but one patient and did not change during the 7-week recovery phase. Seven weeks after HF, a significant positive relationship was observed between the change in calcitriol and serum 25(OH)D concentration (r = 0.385, p = 0.009) and free 25(OH)D (r = 0.296, p = 0.048), and a decrease in calcitriol during recovery was associated with a decrease in serum PTH (p = 0.038). Seven weeks after HF, changes in both serum PTH and serum 25(OH)D concentrations contributed to the prediction of changes in serum calcitriol (R-2 = 0.190, p = 0.012). Conclusions Unlike patients with EHR, subjects with HF had low serum 25(OH)D and low free 25(OH)D concentrations at admission, while their serum 1,25D levels were relatively elevated. Decreases in circulating calcitriol levels in the 7 weeks following hip surgery were associated with a resolution of secondary hyperparathyroidism and low availability of free 25(OH)D.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30202 - Endocrinology and metabolism (including diabetes, hormones)

Návaznosti výsledku

  • Projekt

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2021

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    Journal of endocrinological investigation

  • ISSN

    0391-4097

  • e-ISSN

    1720-8386

  • Svazek periodika

    44

  • Číslo periodika v rámci svazku

    9

  • Stát vydavatele periodika

    US - Spojené státy americké

  • Počet stran výsledku

    9

  • Strana od-do

    1847-1855

  • Kód UT WoS článku

    000611931300002

  • EID výsledku v databázi Scopus

    2-s2.0-85099944136