Low dose NSAIDs and sysadoas in the management of knee osteoarthritis.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023728%3A_____%2F25%3AN0000048" target="_blank" >RIV/00023728:_____/25:N0000048 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/25:10505789

Výsledek na webu

<a href="https://doi.org/10.1007/s40520-025-03221-2" target="_blank" >https://doi.org/10.1007/s40520-025-03221-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s40520-025-03221-2" target="_blank" >10.1007/s40520-025-03221-2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Low dose NSAIDs and sysadoas in the management of knee osteoarthritis.

Popis výsledku v původním jazyce

Osteoarthritis (OA) is a chronic, progressive joint disease characterized by the degradation of articular cartilage, subchondral bone remodeling, synovial inflammation, and osteophyte formation. Despite being a leading cause of disability in older people, effective long-term management of OA remains a significant challenge. Current treatment strategies primarily focus on symptom control, with both non-pharmacological and pharmacological interventions. A systematic literature review followed by a structured Delphi survey was conducted, involving an international Technical Expert Panel (TEP) of OA specialists. The panel evaluated the efficacy, safety, and clinical utility of combining low dose diclofenac and chondroitin sulfate in OA management. The analysis of expert consensus indicated that the combination of low dose diclofenac and chondroitin sulfate may be effective in reducing pain and improving joint function in patients with knee OA. Additionally, this combination could reduce the need for higher doses of NSAIDs, thereby minimizing systemic adverse effects. The combination of low dose diclofenac and chondroitin sulfate represents a promising therapeutic strategy for managing knee OA. Further studies are needed to confirm these findings and optimize therapeutic strategies to improve patient outcomes.

Název v anglickém jazyce

Low dose NSAIDs and sysadoas in the management of knee osteoarthritis.

Popis výsledku anglicky

Osteoarthritis (OA) is a chronic, progressive joint disease characterized by the degradation of articular cartilage, subchondral bone remodeling, synovial inflammation, and osteophyte formation. Despite being a leading cause of disability in older people, effective long-term management of OA remains a significant challenge. Current treatment strategies primarily focus on symptom control, with both non-pharmacological and pharmacological interventions. A systematic literature review followed by a structured Delphi survey was conducted, involving an international Technical Expert Panel (TEP) of OA specialists. The panel evaluated the efficacy, safety, and clinical utility of combining low dose diclofenac and chondroitin sulfate in OA management. The analysis of expert consensus indicated that the combination of low dose diclofenac and chondroitin sulfate may be effective in reducing pain and improving joint function in patients with knee OA. Additionally, this combination could reduce the need for higher doses of NSAIDs, thereby minimizing systemic adverse effects. The combination of low dose diclofenac and chondroitin sulfate represents a promising therapeutic strategy for managing knee OA. Further studies are needed to confirm these findings and optimize therapeutic strategies to improve patient outcomes.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30226 - Rheumatology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

AGING CLINICAL AND EXPERIMENTAL RESEARCH

ISSN

1594-0667

e-ISSN

1720-8319

Svazek periodika

37

Číslo periodika v rámci svazku

Art. Nr. 317

Stát vydavatele periodika

IT - Italská republika

Počet stran výsledku

10

Strana od-do

1-10

Kód UT WoS článku

001609745300001

EID výsledku v databázi Scopus

2-s2.0-105020993107