The translocation of AgNORs in large nucleoli of early granulocyte progenitors in patients suffering from chronic phase of chronic myeloid leukaemia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F09%3A00008293" target="_blank" >RIV/00023736:_____/09:00008293 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The translocation of AgNORs in large nucleoli of early granulocyte progenitors in patients suffering from chronic phase of chronic myeloid leukaemia

Popis výsledku v původním jazyce

The cytochemistry of AgNORs (silver stained nucleolus organizer region proteins such as nucleophosmin, nucleolin, RNA polymerase and UBF) indicated a distinct translocation of these structures to the nucleolar periphery of early granulocytic progenitors.Such phenomenon appears to be one of markers of aging of these cells without the successive differentiation and is related to the loss of the nucleolar biosynthetic activity and cell proliferation. The translocation of AgNORs in granulocytic progenitorswas more expressed in patients treated with imatinib than in patients after interferon therapy. In this connection, it should be mentioned that the incidence of granulocytic cells in patients treated with imatininib was also significantly smaller

Název v anglickém jazyce

The translocation of AgNORs in large nucleoli of early granulocyte progenitors in patients suffering from chronic phase of chronic myeloid leukaemia

Popis výsledku anglicky

The cytochemistry of AgNORs (silver stained nucleolus organizer region proteins such as nucleophosmin, nucleolin, RNA polymerase and UBF) indicated a distinct translocation of these structures to the nucleolar periphery of early granulocytic progenitors.Such phenomenon appears to be one of markers of aging of these cells without the successive differentiation and is related to the loss of the nucleolar biosynthetic activity and cell proliferation. The translocation of AgNORs in granulocytic progenitorswas more expressed in patients treated with imatinib than in patients after interferon therapy. In this connection, it should be mentioned that the incidence of granulocytic cells in patients treated with imatininib was also significantly smaller

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Applied Biomedicine : JAB

ISSN

1214-021X

e-ISSN

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Svazek periodika

7

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

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Kód UT WoS článku

000267953800005

EID výsledku v databázi Scopus

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